Base de datos : IBECS
Búsqueda : "1138-7548" [ISSN]
Referencias encontradas : 787 [refinar]
Mostrando: 1 .. 10   en el formato [Detallado]

página 1 de 79 va a la página                         

  1 / 787 IBECS  
              next record last record
selecciona
para imprimir
Id: 179044
Autor: Catalano-Iniesta, Leonardo; Iglesias-Osma, María Carmen; Sánchez-Robledo, Virginia; Carretero-Hernández, Marta; Blanco, Enrique J; Carretero, José; García-Barrado, María José.
Título: Variations in adrenal gland medulla and dopamine effects induced by the lack of Irs2
Fuente: J. physiol. biochem;74(4):667-677, nov. 2018. graf, ilus, tab.
Idioma: en.
doi: 10.1007/s13105-018-0655-8.
Resumen: The adrenomedullary chromaffin cells' hormonal pathway has been related to the pathophysiology of diabetes mellitus. In mice, the deletion of insulin receptor substrate type 2 (Irs2) causes peripheral insulin resistance and reduction in Beta-cell mass, leading to overt diabetes, with gender differences on adrenergic signaling. To further unravel the relevance of Irs2 on glycemic control, we analyzed in adult Irs2 deficient (Irs2-/-) mice, of both sexes but still normoglycemic, dopamine effects on insulin secretion and glycerol release, as well as their adrenal medulla by an immunohistochemical and morphologic approach. In isolated islets, 10 μM dopamine significantly inhibited insulin release in wild-type (WT) and female Irs2−/− mice; however, male Irs2−/− islets were insensitive to that catecholamine. Similarly, on isolated adipocytes, gender differences were observed between WT and Irs2-/- mice in basal and evoked glycerol release with crescent concentrations of dopamine. By immunohistochemistry, reactivity to tyrosine hydroxylase (TH) in female mice was significantly higher in the adrenal medulla of Irs2-/- compared to WT; although no differences for TH-immunopositivity were observed between the male groups of mice. However, compared to their corresponding WT animals, adrenomedullary chromaffin cells of Irs2-/- mice showed a significant decrease in the cellular and nuclear areas, and even in their percentage of apoptosis. Therefore, our observations suggest that, together with gender differences on dopamine responses in Irs2-/- mice, disturbances in adrenomedullary chromaffin cells could be related to deficiency of Irs2. Accordingly, Irs2 could be necessary for adequate glucose homeostasis and maintenance of the population of the adrenomedullary chromaffin cells

No disponible
Descriptores: médula suprarrenal/metabolismo
dopamina/metabolismo
hiperinsulinismo/metabolismo
proteínas sustrato del receptor de insulina/metabolismo
proteínas sustrato del receptor de insulina/metabolismo
islotes pancreáticos/metabolismo
estado prediabético/metabolismo
-adipocitos blancos
hiperinsulinismo/sangre
hiperinsulinismo/patología
técnicas in vitro
proteínas sustrato del receptor de insulina/genética
islotes pancreáticos/patología
estado prediabético/patología
Límites: animales
masculino
femenino
ratones
Responsable: BNCS


  2 / 787 IBECS  
              first record previous record next record last record
selecciona
para imprimir
Id: 179043
Autor: Miranda, Jonatan; Eseberri, Itziar; Lasa, Arrate; Portillo, María P.
Título: Lipid metabolism in adipose tissue and liver from diet-induced obese rats: a comparison between Wistar and Sprague-Dawley strains
Fuente: J. physiol. biochem;74(4):655-666, nov. 2018. tab, graf.
Idioma: en.
doi: 10.1007/s13105-018-0654-9.
Resumen: Some researchers have proposed important variations in adipose tissue among different strains of rats and mice in response to a high-caloric (hc) diet, but data concerning the mechanisms underlying these differences are scarce. The aim of the present research was to characterize different aspects of triacylglycerol (TG) metabolism and clock genes between Sprague-Dawley and Wistar rats. For this purpose, 16 male Sprague-Dawley and 16 male Wistar rats were divided into four experimental groups (n = 8) and fed either a normal-caloric (nc) diet or a hc diet for 6 weeks. After sacrifice, liver and epididymal, perirenal, mesenteric, and subcutaneous adipose tissue depots were dissected, weighed and immediately frozen. Liver TG content was quantified, RNA extracted for gene expression analysis and fatty acid synthase enzyme activity measured. Two-way ANOVA and Student's t test were used to perform the statistical analyses. Under hc feeding conditions, Wistar rats were more prone to fat accumulation in adipose tissue, especially in the epididymal fat depot, due to their increased lipogenesis and fatty acid uptake. By contrast, both strains of rats showed similarly fatty livers after hc feeding. Peripheral clock machinery seems to be a potential explanatory mechanism for Wistar and Sprague-Dawley strain differences. In conclusion, Wistar strain seems to be the best choice as animal model in dietary-induced obesity studies

No disponible
Descriptores: alimentación rica en grasa/efectos adversos
modelos de enfermedad en animales
grasa intraabdominal/metabolismo
lipogénesis
hígado/metabolismo
-adipocitos
proteínas CLOCK
triglicéridos/metabolismo
ratas Wistar
Límites: animales
masculino
ratas
Tipo de Publicación: estudio comparativo
Responsable: BNCS


  3 / 787 IBECS  
              first record previous record next record last record
selecciona
para imprimir
Id: 179042
Autor: Astre, Gwendoline; Deleruyelle, Simon; Dortignac, Alizée; Bonnet, Christelle.
Título: Diet-induced obesity and associated disorders are prevented by natural bioactive type 1 fish collagen peptides (Naticol(R)) treatment
Fuente: J. physiol. biochem;74(4):647-654, nov. 2018. tab.
Idioma: en.
doi: 10.1007/s13105-018-0650-0.
Resumen: To fight against metabolic disorders such as insulin resistance, new alimentary behaviors are developed. For instance, hyperproteined, gluten-free, or collagen-enriched diets could be preconized in order to reduce the consequences of obesity. In this aim, this study evaluates the potential effects of warm sea fish collagen peptides (Naticol(R)) on representative metabolic and inflammatory parameters. For that, male C57Bl6/J mice fed with either a chow- (CD) or high-fat diet (HFD) were submitted or not to specific collagen peptides in drinking water (4 g/kg bw/d) for 20 weeks. Weight, body composition, glucose tolerance, and insulin sensitivity were followed up. Effects of fish collagen peptides on various blood parameters reflecting the metabolism status were also measured (free fatty acids, triglycerides, cholesterol, hormones) together with adipocyte inflammation. Results showed that HFD-fed mice supplemented by fish collagen peptides exhibited a significant lower increase in body weight as soon as the twelfth week of treatment whereas no effect of the peptide was observed in CD fed mice. In line with this result, a weaker increase in fat mass in HFD-fed mice supplemented with Naticol(R) at both 9 and 18 weeks of treatment was also observed. In spite of this resistance to obesity promoted by fish collagen peptides treatment, no difference in glucose tolerance was found between groups whereas mice treated with Naticol(R) exhibited a lower basal glycemia. Also, even if no effect of the treatment on adipocyte lipolysis was found, a decrease of inflammatory cytokines was retrieved in collagen-supplemented group arguing for a potential better insulin sensitivity. Altogether, these results need to be completed but are the first describing a benefic role of warm sea fish collagen peptides in a context of metabolic disease paving the route for a potential utilization in human obesity-associated disorders

No disponible
Descriptores: fármacos antiobesidad/uso terapéutico
colágeno/uso terapéutico
suplementos dietéticos
resistencia a la insulina
proteínas de pescado/uso terapéutico
obesidad/terapia
fragmentos peptídicos/uso terapéutico
-tejido adiposo/inmunología
tejido adiposo/metabolismo
antiinflamatorios no esteroideos/efectos adversos
antiinflamatorios no esteroideos/metabolismo
fármacos antiobesidad/efectos adversos
fármacos antiobesidad/metabolismo
colágeno/efectos adversos
colágeno/metabolismo
citocinas
Límites: animales
masculino
ratones
Responsable: BNCS


  4 / 787 IBECS  
              first record previous record next record last record
selecciona
para imprimir
Id: 179041
Autor: Iñiguez, María; Pérez-Matute, Patricia; Villanueva-Millán, María Jesús; Recio-Fernández, Emma; Roncero-Ramos, Irene; Pérez-Clavijo, Margarita; Oteo, José-Antonio.
Título: Agaricus bisporus supplementation reduces high-fat diet-induced body weight gain and fatty liver development
Fuente: J. physiol. biochem;74(4):635-646, nov. 2018. tab, graf, ilus.
Idioma: en.
doi: 10.1007/s13105-018-0649-6.
Resumen: Obesity is a global epidemic characterized not only by excessive fat deposition but also by important complications such as nonalcoholic liver steatosis. Beneficial antiobesogenic effects have been described for some mushrooms. The current study aimed to demonstrate the protective effect of Agaricus bisporus (AB) supplementation against the metabolic alterations induced by high-fat-diet (HFD) feeding. Eight-week-old C57BL/6J mice were fed for 10 weeks with one of the following diets: (1) control diet (n = 7), (2) HFD (n = 7), (3) HFD supplemented with 5% AB (n = 9), and (4) HFD supplemented with 10% AB (n = 9). A pair-fed group was also included for the 10% AB group (n = 6). The impact of AB supplementation on food intake, body weight gain, and liver and fat pad weights was examined. Biochemical, histological, and molecular parameters were also analyzed. Dietary supplementation with 10% AB reduced the HFD-induced increase in body, epididymal, and mesenteric fat weights (p < 0.01, p < 0.05, and p < 0.05, respectively). Supplementation with AB also reduced liver damage in a dose-dependent manner (p < 0.01 and p < 0.001). This effect was confirmed by histological analysis that showed that liver steatosis was markedly reduced in mice fed with AB. The beneficial properties of 10% AB supplementation appear to be mediated through a decrease in food intake and via stimulation of mesenteric and hepatic free-fatty acid beta-oxidation, along with a decrease in epidydimal and hepatic expression of CD36. In conclusion, supplementation with AB prevents excessive body weight gain and liver steatosis induced by HFD consumption

No disponible
Descriptores: Agaricus/química
fármacos antiobesidad/uso terapéutico
productos biológicos/uso terapéutico
suplementos dietéticos
lipotrópicos/uso terapéutico
esteatosis hepática no alcohólica/prevención & control
obesidad/prevención & control
-adiposidad
fármacos antiobesidad/administración & dosificación
productos biológicos/administración & dosificación
antígenos CD36
lipotrópicos/administración & dosificación
esteatosis hepática no alcohólica/etiología
esteatosis hepática no alcohólica/metabolismo
esteatosis hepática no alcohólica/patología
Límites: animales
masculino
ratones
Tipo de Publicación: estudio comparativo
Responsable: BNCS


  5 / 787 IBECS  
              first record previous record next record last record
selecciona
para imprimir
Id: 179040
Autor: Carpéné, Christian; Galitzky, Jean; Belles, Chloé; Zakaroff-Girard, Alexia.
Título: Mechanisms of the antilipolytic response of human adipocytes to tyramine, a trace amine present in food
Fuente: J. physiol. biochem;74(4):623-633, nov. 2018. tab, graf.
Idioma: en.
doi: 10.1007/s13105-018-0643-z.
Resumen: Tyramine is found in foodstuffs, the richest being cheeses, sausages, and wines. Tyramine has been recognized to release catecholamines from nerve endings and to trigger hypertensive reaction. Thereby, tyramine-free diet is recommended for depressed patients treated with irreversible inhibitors of monoamine oxidases (MAO) to limit the risk of hypertension. Tyramine is a substrate of amine oxidases and also an agonist at trace amine-associated receptors. Our aim was to characterize the dose-dependent effects of tyramine on human adipocyte metabolic functions. Lipolytic activity was determined in adipocytes from human subcutaneous abdominal adipose tissue. Glycerol release was increased by a fourfold factor with classical lipolytic agents (1 μM isoprenaline, 1 mM isobutylmethylxanthine) while the amine was ineffective from 0.01 to 100 μM and hardly stimulatory at 1 mM. Tyramine exhibited a partial antilipolytic effect at 100 μM and 1 mM, which was similar to that of insulin but weaker than that obtained with agonists at purinergic A1 receptors, α2-adrenoceptors, or nicotinic acid receptors. Gi-protein blockade by Pertussis toxin abolished all these antilipolytic responses save that of tyramine. Indeed, tyramine antilipolytic effect was impaired by MAO-A inhibition. Tyramine inhibited protein tyrosine phosphatase activities in a manner sensitive to ascorbic acid and amine oxidase inhibitors. Thus, millimolar tyramine restrained lipolysis via the hydrogen peroxide it generates when oxidized by MAO. Since tyramine plasma levels have been reported to reach 0.2 μM after ingestion of 200 mg tyramine in healthy individuals, the direct effects we observed in vitro on adipocytes could be nutritionally relevant only when the MAO-dependent hepato-intestinal detoxifying system is overpassed

No disponible
Descriptores: inhibidores de la captación adrenérgica/efectos adversos
grasa subcutánea/metabolismo
tiramina/efectos adversos
-toxina de adenilato ciclasa/farmacología
agonistas de receptores adrenérgicos alfa-2/farmacología
inhibidores de la captación adrenérgica/química
agonistas adrenérgicos beta/farmacología
inhibidores enzimáticos/farmacología
glicerol/metabolismo
grasa subcutánea/citología
grasa subcutánea
tiramina/antagonistas & inhibidores
Límites: seres humanos
femenino
adulto
Responsable: BNCS


  6 / 787 IBECS  
              first record previous record next record last record
selecciona
para imprimir
Id: 179039
Autor: Perez-Diaz, Sergio; Garcia-Sobreviela, Maria P; Gonzalez-Irazabal, Yolanda; Garcia-Rodriguez, Beatriz; Espina, Silvia; Arenaz, Izaskun; Arbones-Maina, Jose M.
Título: PTRF acts as an adipokine contributing to adipocyte dysfunctionality and ectopic lipid deposition
Fuente: J. physiol. biochem;74(4):613-622, nov. 2018. ilus, graf.
Idioma: en.
doi: 10.1007/s13105-018-0638-9.
Resumen: Adipose tissue (AT) expands under obesogenic conditions. Yet, when the growth exceeds a certain limit, AT becomes dysfunctional and surplus lipids start depositing ectopically. Polymerase I and transcription release factor (PTRF) has been proposed as a mechanism leading to a dysfunctional AT by decreasing the adipogenic potential of human adipocyte precursors. However, whether or not PTRF can be secreted by the adipocytes into the bloodstream is not yet known. For this work, PTRF presence was investigated in plasma. We also produced a recombinant PTRF (rPTRF) and examined its impact on the functional interactions between the adipocyte and the hepatocyte in vitro. We demonstrated that PTRF can be found in human plasma, and is at least in part, carried by exosomes. In vitro treatment with rPTRF increased the hypertrophy and senescence of 3T3-L1 adipocytes. In turn, those rPTRF-treated adipocytes increased lipid accumulation in hepatocytes. Lastly, we found a positive correlation between circulating PTRF and the concentration of PTRF in the visceral fat depot. All these findings point toward the presence of an enlarged and dysfunctional visceral adipose tissue which secretes PTRF. This circulating PTRF behaves as an adipokine and may partially contribute to the well-known detrimental effects of visceral fat accumulation

No disponible
Descriptores: exosomas/metabolismo
grasa intraabdominal/metabolismo
metabolismo lipídico
proteínas de membranas/metabolismo
obesidad/metabolismo
proteínas de unión al ARN/metabolismo
-células 3T3-L1
absorción fisiológica
senescencia celular
estudios de cohortes
grasa intraabdominal/patología
grasa intraabdominal/ultraestructura
Límites: seres humanos
animales
masculino
femenino
ratones
Tipo de Publicación: estudio comparativo
Responsable: BNCS


  7 / 787 IBECS  
              first record previous record next record last record
selecciona
para imprimir
Id: 179038
Autor: Nassra, Merian; Bourgeois, Christine; Subirade, Muriel; Sauvant, Patrick; Atgié, Claude.
Título: Oral administration of lipid oil-in-water emulsions performed with synthetic or protein-type emulsifiers differentially affects post-prandial triacylglycerolemia in rats
Fuente: J. physiol. biochem;74(4):603-612, nov. 2018. graf, tab.
Idioma: en.
doi: 10.1007/s13105-018-0634-0.
Resumen: In this study, we compared the impact of administration of size-calibrated lipid emulsions prepared with either synthetic or natural emulsifiers on the post-absorptive plasma triacylglycerol responses in rats. We did this using four types of size-calibrated (10 mim diameter) and metastable (3 days) emulsions with 20% of an oleic acid-rich sunflower oil and 1% of either synthetic emulsifiers (Tween 80 or sodium 2-stearoyl-lactylate) or two proteins (β-lactoglobulin or sodium caseinate). An oral fat tolerance test was performed in fasted rats by oral administration of each of these formulations in continuous or emulsified forms. Kinetic parameters (AUC0-inf., AUC0-6h, Cmax, Tmax, and T1/2) for the description of the plasma triacylglycerol responses were calculated. AUC0-6h and AUC0-inf. calculated for the protein groups were significantly lower than those of the control and the synthetic groups. These lower values were associated with significant decreases in the Cmax, exacerbated by the emulsion form and with marked decreases in the Tmax as compared to the control group. T1/2 values were differentially affected by the lipid administration forms and by the nature of the emulsifiers. As compared with the control group, T1/2 was largely increased in the sodium stearoyl-2-lactylate group, but on the contrary, largely lowered in the casein group. We concluded that the use of proteins as natural emulsifiers in lipid emulsions decreased the magnitude of post-prandial triacylglycerolemia for the same amount of ingested lipids, when the emulsion size is controlled for. Proteins could be a promising alternative to the widespread use of synthetic emulsifiers in the food industry

No disponible
Descriptores: grasas dietéticas insaturadas/administración & dosificación
proteínas de la dieta/química
emulsionantes/química
aditivos alimentarios/química
hipertrigliceridemia/prevención & control
ácido oleico/administración & dosificación
aceite de cártamo/administración & dosificación
-área bajo la curva
caseínas/efectos adversos
caseínas/química
grasas dietéticas insaturadas/efectos adversos
proteínas de la dieta/efectos adversos
emulsionantes/efectos adversos
aditivos alimentarios/efectos adversos
hipertrigliceridemia/sangre
lactoglobulinas
aceite de cártamo/efectos adversos
Límites: animales
masculino
ratas
Tipo de Publicación: estudio comparativo
Responsable: BNCS


  8 / 787 IBECS  
              first record previous record next record last record
selecciona
para imprimir
Id: 179037
Autor: Clément, Andrée-Anne; Riesco, Eléonor; Tessier, Sébastien; Lacaille, Michel; Pérusse, Francine; Coté, Mélanie; Després, Jean-Pierre; Weisnagel, John; Doré, Jean; Joanisse, Denis R; Mauriège, Pascale.
Título: The relationship between adiposopathy and glucose-insulin homeostasis is not affected by moderate-intensity aerobic training in healthy women with obesity
Fuente: J. physiol. biochem;74(4):591-601, nov. 2018. tab, graf.
Idioma: en.
doi: 10.1007/s13105-018-0630-4.
Resumen: The contribution of adiposopathy to glucose-insulin homeostasis remains unclear. This longitudinal study examined the potential relationship between the adiponectin/leptin ratio (A/L, a marker of adiposopathy) and insulin resistance (IR: homeostasis model assessment (HOMA)), insulin sensitivity (IS: Matsuda), and insulin response to an oral glucose tolerance test before and after a 16-week walking program, in 29 physically inactive pre- and postmenopausal women with obesity (BMI, 29-35 kg/m2; age, 47-54 years). Anthropometry, body composition, VO2max, and fasting lipid-lipoprotein and inflammatory profiles were assessed. A/L was unchanged after training (p = 0.15), despite decreased leptin levels (p < 0.05). While the Matsuda index tended to increase (p = 0.07), HOMA decreased (p < 0.05) and fasting insulin was reduced (p < 0.01) but insulin area under the curve (AUC) remained unchanged (p = 0.18) after training. Body fatness and VO2max were improved (p < 0.05) while triacylglycerols increased and HDL-CHOL levels decreased after training (p < 0.05). At baseline, A/L was positively associated with VO2max, HDL-CHOL levels, and Matsuda (0.37 < ρ < 0.56; p < 0.05) but negatively with body fatness, HOMA, insulin AUC, IL-6, and hs-CRP levels (− 0.41 < ρ < − 0.66; p < 0.05). After training, associations with fitness, HOMA, and inflammation were lost. Multiple regression analysis revealed A/L as an independent predictor of IR and IS, before training (partial R2 = 0.10 and 0.22), although A/L did not predict the insulin AUC pre- or post-intervention. A significant correlation was found between training-induced changes to A/L and IS (r = 0.38; p < 0.05) but not with IR or insulin AUC. Although changes in the A/L ratio could not explain improvements to glucose-insulin homeostasis indices following training, a relationship with insulin sensitivity was revealed in healthy women with obesity

No disponible
Descriptores: adiponectina/sangre
adiposidad
resistencia a la insulina
leptina/sangre
obesidad metabólicamente benigna/terapia
acondicionamiento físico humano
salud urbana
-biomarcadores/sangre
índice de masa corporal
prueba de tolerancia a la glucosa
estudios longitudinales
obesidad metabólicamente benigna/sangre
obesidad metabólicamente benigna/inmunología
obesidad metabólicamente benigna/metabolismo
Límites: seres humanos
femenino
persona de mediana edad
Tipo de Publicación: estudio comparativo
Responsable: BNCS


  9 / 787 IBECS  
              first record previous record next record last record
selecciona
para imprimir
Id: 179036
Autor: Marques-Rocha, JL; Garcia-Lacarte, M; Samblas, M; Bressan, J; Martínez, JA; Milagro, FI.
Título: Regulatory roles of miR-155 and let-7b on the expression of inflammation-related genes in THP-1 cells: effects of fatty acids
Fuente: J. physiol. biochem;74(4):579-589, nov. 2018. graf.
Idioma: en.
doi: 10.1007/s13105-018-0629-x.
Resumen: The main aim of this investigation was to study the regulatory roles of let-7b and miR-155-3p on the expression of inflammation-associated genes in monocytes, macrophages, and lipopolysaccharide (LPS)-activated macrophages (AcM). A second goal was to analyze the potential modulatory roles of different fatty acids, including oleic, palmitic, eicosapentaenoic (EPA), and docosahexaenoic (DHA), on the expression of these miRNAs in the three cell types. This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24 h. Monocytes, macrophages, and AcM were transfected with a negative control, or mimics for miR-155-3p and miR-let-7b-5p. The expression of both miRNAs and some proinflammatory genes was analyzed by qRT-PCR. Interestingly, let-7b mimic reduced the expression of IL6 and TNF in monocytes, and SERPINE1 expression in LPS-activated macrophages. However, IL6, TNF, and SERPINE1 were upregulated in macrophages by let-7b mimic. IL6 expression was higher in the three types of cells after transfecting with miR-155-3p mimic. Similarly, expression of SERPINE1 was increased by miR-155-3p mimic in monocytes and macrophages. However, TLR4 was downregulated by miR-155-3p in monocytes and macrophages. Regarding the effects of the different fatty acids, oleic acid increased the expression of let-7b in macrophages and AcM and also increased the expression of miR-155 in monocytes when compared with DHA but not when compared with non-treated cells. Overall, these results suggest anti- and proinflammatory roles of let-7b and miR-155-3p in THP-1 cells, respectively, although these outcomes are strongly dependent on the cell type. Noteworthy, oleic acid might exert beneficial anti-inflammatory effects in immune cells (i.e., non-activated and LPS-activated macrophages) by upregulating the expression of let-7b

No disponible
Descriptores: ácidos grasos no esterificados/metabolismo
macrófagos/metabolismo
microARN/metabolismo
monocitos/metabolismo
-diferenciación celular
ácidos docosahexaenoicos/metabolismo
regulación negativa
interleucina-6/agonistas
interleucina-6/antagonistas & inhibidores
interleucina-6/genética
lipopolisacáridos/toxicidad
activación de macrófagos
microARN/química
Límites: seres humanos
Tipo de Publicación: estudio comparativo
Responsable: BNCS


  10 / 787 IBECS  
              first record previous record
selecciona
para imprimir
Id: 179035
Autor: Gatineau, Eva; Capel, Frédéric; Dardevet, Dominique; David, Jérémie; Pouyet, Corinne; Polakof, Sergio; Mosoni, Laurent.
Título: Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients
Fuente: J. physiol. biochem;74(4):569-577, nov. 2018. graf.
Idioma: en.
doi: 10.1007/s13105-018-0628-y.
Resumen: High-sugar intake and senescence share common deleterious effects, in particular in liver, but combination of these two factors was little studied. Our aims were to examine the effect of a high-sucrose diet in liver of old rats and also the potential benefices of a polyphenol/micronutrient supplementation. Four groups of 22-month-old male rats fed during 5 months with a diet containing either 13 or 62% sucrose, supplemented or not with rutin, vitamin E, A, D, selenium, and zinc were compared. We measured liver macronutrient composition, glycation/oxidative stress, enzyme activities (lipogenesis, Beta-oxidation, fructokinase), gene expression (enzymes and transcription factors), in vivo protein synthesis rates and plasma parameters. Sucrose induced an increase in plasma and liver lipid content, and a stimulation of liver protein synthesis rates. Gene expression was little changed by sucrose, with lower levels for LXR-alfa and LXR-Beta. Polyphenol/micronutrient supplementation tended to limit liver triglyceride infiltration through variations in fatty acid synthase, acyl coA oxidase, and possibly ATP-citrate lyase activities. In conclusion, despite differences in enzymatic regulations, and blunted responses of gene expression, high-sucrose diet was still able to induce a marked increase in liver lipid content in old animals. However, it probably attenuated the positive impact of polyphenol/micronutrients

No disponible
Descriptores: envejecimiento
antioxidantes/uso terapéutico
suplementos dietéticos
hígado/metabolismo
esteatosis hepática no alcohólica/prevención & control
rutina/uso terapéutico
-antioxidantes/metabolismo
dieta de carga de carbohidratos/efectos adversos
regulación de la expresión génica en el desarrollo
glicosilación
metabolismo lipídico
hígado/crecimiento & desarrollo
micronutrientes/uso terapéutico
esteatosis hepática no alcohólica/metabolismo
estrés oxidativo
ratas Wistar
Límites: animales
masculino
ratas
Responsable: BNCS



página 1 de 79 va a la página                         
   


Refinar la búsqueda
  Base de datos : IBECS Formulario avanzado   
Buscar por : Formulario libre    Formulario básico

    Buscar en el campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPS/OMS - Centro Latinoamericano y del Caribe de Información en Ciencias de la Salud