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Id:	231234
Autor:	Sánchez-Jorge, María Isabel; Cortés Bretón Brinkmann, Jorge; Acevedo Ocaña, Rosa; Quispe López, Norberto; Falahat, Farzin; Martín Granizo, Rafael.
Título:	Perceived surgical difficulty of mandibular third molar extraction. A comparative cross-sectional study of dentists with postgraduate qualificationin oral surgery and maxillofacial surgeons in a Spanish subpopulation
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e263-272, Mar. 2024. tab, ilus, graf.
Idioma:	en.
doi:	10.4317/medoral.26243.
Resumen:	Background: Mandibular third molar (MTM) extraction is one of the most frequently performed surgeries in the oral cavity. Establishing the level of surgical difficulty pre-operatively is an essential step to ensure correct treatment planning. In Spain, MTM extraction - especially in cases presenting greater difficulty - is normally performed by doctors specializing in oral and maxillofacial surgery, or by dentists with postgraduate qualifications in oral surgery. The present work set out to analyze the extent to which perceptions of surgical difficulty of the said intervention vary in relation to professional training. Material and Methods: This cross-sectional, descriptive, observational study took the form of a survey. Using a visual analog scale (VAS), participants evaluated both the perceived difficulty of 30 cases of MTM extraction described by means of digital panoramic radiographs and the perceived difficulty deriving from a series of factors conditioning MTM extraction. The results underwent statistical analysis with SPSS Statistics 28.0 software. Nonparametric tests (Mann Whitney test for independent samples and the Kruskal-Wallis test) were applied. Results: A total of 213 surveys were available for analysis. Both groups awarded the greatest importance to clinical experience, followed by anatomical and radiographic factors, root morphology obtaining the highest score among anatomical factors (9.01±1.42), while proximity of the MTM to the inferior alveolar nerve was regarded as the least important anatomical factor (8.11 ±2.54). Significant differences were only found for patient age, whereby maxillofacial surgeons awarded this factor more importance than dentists. Conclusions: The different training received by dentists specialized in oral surgery and maxillofacial surgeons did not influence either perceptions of surgical difficulty of MTM extraction, or opinions as to the factors influencing surgical difficulty. (AU)
Descriptores:	tercer molar boca cirugía general cirugía oral Cirujanos orales y maxilofaciales
	-España estudios transversales epidemiología descriptiva
Límites:	seres humanos
Tipo de Publicación:	estudio observacional
Responsable:	ES15.1 - BNCS

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Id:	231233
Autor:	Silva, Paulo Goberlânio de Barros; Paula, Dayrine Silveira de; Soares, Guilherme Costa; Cavalcante, Lirya Nágyla de Souza; Nascimento, Isabelly Vidal do; Sousa, Fabrício Bitu; Mota, Mário Rogério Lima; Alves, Ana Paula Negreiros Nunes.
Título:	Role of collagen and immunostaining for TGF-β in the clinical andmicroscopic findings of pyogenic granuloma and peripheral ossifying fibroma
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e288-e296, Mar. 2024. tab, ilus.
Idioma:	en.
doi:	10.4317/medoral.26268.
Resumen:	Background: Collagen is a component of Pyogenic Granuloma (PG) and Peripheral Ossifying Fibroma (POF) and performs different functions in these lesions. The objective of this study is to evaluate the role of collagen and immunostaining for Transforming Growth Factor beta (TGF-β) in the clinical and microscopic findings of PG and POF. Material and Methods: PG (n=20) and POF (n=20) were selected for clinical evaluation (sex, age, localization, size and evolution time) and microscopic analysis (picrosirius red staining for collagen analysis and immunohistochemistry for TGF-β) performed in the superficial and deep areas of the two lesions. ANOVA/Bonferroni and t-test, Pearson correlation and χ2 were used to compare the sites and parameters analyzed (p<0.05, GraphPad Prism 5.0). Results: The depth of PG presented the highest amount of collagen (p<0.001), and its surface showed the lowest amount of type 1 collagen (yellow-red strong birefringence). Type 1 collagen gradually increased in depth of PG, surface and depth of POF (p<0.001). The number of TGF-β+ cells was lower on the surface of PG compared with the depth of PG and the two areas of POF (p<0.001). Sex and localization did not affect these parameters, but the profile of collagen and immunostaining for TGF-β suffered from modifications by the time of evolution and the size of the lesion. Conclusions: Although PG and POF are reactive gingival lesions, the expression of TGF-β and its role in collagen showed different biological behaviors in these lesions, suggesting different biological origins for its components. (AU)
Descriptores:	colágeno fibroma osificante sexo SELECCION DEL EMPLAZAMIENTO DE TRATAMIENTO DE RESIDUOS heridas y lesiones células
Límites:	seres humanos
Tipo de Publicación:	estudio observacional
Responsable:	ES15.1 - BNCS

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Id:	231232
Autor:	Silva, Luan César; Oliveira, Maria Eduarda Pérez de; Pedroso, Caique Mariano; Leite, Amanda Almeida; Silva, Alan Roger Santos; Lopes, Marcio Ajudarte; Castro Junior, Gilberto de; Martins, Manoela Domingues; Petersen Wagner, Vivian; Kowalski, Luiz Paulo.
Título:	Systemic therapies for salivary gland carcinomas: an overview of published clinical trials
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e280-e287, Mar. 2024. mapas, tab.
Idioma:	en.
doi:	10.4317/medoral.26264.
Resumen:	Background: There is no consensus about effective systemic therapy for salivary gland carcinomas (sgcs). Our aim was summarized the clinical trials assessing the systemic therapies (ST) on sgcs.Material and Methods: Electronic searches were carried out through MEDLINE/pubmed, EMBASE, Scopus, Web of Science, and the Cochrane Library databases, and gray literature. Results: Seventeen different drugs were evaluated, and the most frequent histological subtype was adenoid cysticcarcinoma (n=195, 45.5%). Stable disease, observed in 11 ST, achieved the highest rate in adenoid cystic carcinoma treated with sunitinib. The highest complete (11.1%) and partial response (30.5%) rates were seen in androgen receptor-positive tumors treated with leuprorelin acetate. Conclusions: Despite all the advances in this field, there is yet no effective evidence-based regimen of ST, with all the clinical trials identified showing low rates of complete and partial responses. Further, translational studies are urgently required to characterize molecular targets and effective ST. (AU)
Descriptores:	preparados farmacéuticos carcinoma adenoide quístico sunitinib andrógenos neoplasias leuprolida
	-carcinoma
Límites:	seres humanos
Tipo de Publicación:	ensayo clínico estudio comparativo
Responsable:	ES15.1 - BNCS

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Id:	231231
Autor:	Cuellar, Ana Guadalupe Gama; Pulido Díaz, Katya; Martínez Calleja, Mariana; Anaya Saavedra, Gabriela; Ramírez Amador, Velia; Rodarte Corro, Jorge; Ramón Ramírez, Victor; Albuquerque Júnior, Ricardo Luiz; Gondak, Rogério.
Título:	Impaired intratumoral dendritic cell function and potential predictive value of dendritic cells markers for metastasis in malignant salivary gland tumors
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e273-e279, Mar. 2024. tab, ilus.
Idioma:	en.
doi:	10.4317/medoral.26248.
Resumen:	Background: The differentiation between primary and metastatic salivary gland neoplasms (SGNs) helps in determining appropriate management strategies, including the need for additional diagnostic tests, surveillance, or aggressive treatment. The purpose of this study was to identify and quantify the immature and mature dendritic cells (DCs) in metastatic and no metastatic SGNs and determine its association with clinicopathological findings. Material and Methods: Cross-sectional, observational, and descriptive study that includes 33 malignant salivary gland neoplasms [MSGN (6, 18.1% metastatic)], and 22 pleomorphic adenomas (PA), as a control group. Clinical and histopathological characteristics were obtained. Immunohistochemistry for human leukocyte antigen Drelated (HLA-DR), CD1a, CD83, and Ki-67 proteins was done. Positive intra- and peritumoral DCs were counted. Results: Individuals with MSGN had a lower density of intratumoral HLA-DR+ cells than those with PA (p=0.001), Ki-67 immunostaining was significantly higher in MSGN than in PA (6% vs. 1.4%, p<0.001). Metastatic MSGN showed less intratumoral CD1a+ than non-metastatic (3.2 vs. 165.1, p=0.001). No differences in intra- and peritumoral CD83+ cells were found between benign and malignant SGN. Conclusions: These results suggest that the immune-protective function of intratumoral DCs is compromised in MSGNs. DCs markers may represent useful prediction tools for metastases in salivary gland malignancies, with crucial implications in the implementation of appropriate disease management strategies. (AU)
Descriptores:	neoplasias glándulas salivales diagnóstico terapéutica células dendríticas inmunohistoquímica antígenos HLA
	-estudios transversales epidemiología descriptiva
Límites:	seres humanos
Tipo de Publicación:	estudio observacional
Responsable:	ES15.1 - BNCS

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Id:	231230
Autor:	Tapia, Pedro; Matus Miranda, Gustavo; Díaz, Fernanda; Arrué, Pablo.
Título:	Preservation of the inferior alveolar vasculonervous bundle in mandibular resective therapies: systematic review and report of two cases
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e255-e262, Mar. 2024. ilus, tab, graf.
Idioma:	en.
doi:	10.4317/medoral.26239.
Resumen:	Background: Segmental surgical resection is a frequently indicated procedure to treat aggressive mandibular tumors. One of the most important complications derived from this technique is permanent paresthesia of the inferior alveolar nerve (IAN), which significantly affects the quality of life of patients who experience it. This could be avoided through maneuvers that preserve the IAN. The objective of this paper is to review the main techniques for IAN preservation and to present 2 cases with the technique used by the author. Material and Methods: A systematic review was performed according to the PRISMA guidelines, apropos of two clinical cases reported in this study. The MEDLINE/PubMed and Scopus databases were searched. Several variables were considered and are presented in detail in the form of tables and figures. In addition, 2 case reports with NAI preservation techniques are presented. Results: 13 articles were finally obtained for analysis. 127 patients were evaluated, reporting mandibular resections associated with various pathologies. Various surgical techniques were used, all with the same goal of maintaining the IAN. In most of the patients, the maintenance of sensitivity was achieved, which was verified with different methods. Conclusions: Preservation of the IAN in maxillofacial surgical procedures where surgical resection of the mandibular bone has been performed is an alternative that has demonstrated successful results in terms of reducing postoperative sequelae and is currently positioned as a necessary and feasible procedure. (AU)
Descriptores:	traumatismos mandibulares neoplasias parestesia nervio mandibular calidad de vida patología bucal cirugía oral
Límites:	seres humanos
Tipo de Publicación:	informes de casos revisión sistemática
Responsable:	ES15.1 - BNCS

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Id:	231229
Autor:	Martin, Joyce Ohana de Lima; Borges, Marcela Maria Fontes; Malta, Cássia Emmanuela Nóbrega; Guerra, Janaina Motta; Alves Crispim, André; Coelho, Bruna Carolina; Silva, Lúcio Flávioi Gonzaga; Silva, Paulo Goberlânio de Barros.
Título:	Risk factors for oral mucositis in patients with solid tumorsunder treatment with cetuximab: a retrospective cross-sectional study
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e248-e254, Mar. 2024. graf, tab.
Idioma:	en.
doi:	10.4317/medoral.26237.
Resumen:	Background: This study retrospectively analyzed the risk factors for oral mucositis (OM) during cetuximab treatment. Material and Methods: We screened patients using cetuximab and retrospectively evaluated the presence of OM based on medical records. We collected information from 2 years of evaluations. Patient medical records were reviewed to obtain data on chemotherapy cycle and dose, sex, age, primary tumor, TNM stage, and head and neck radiotherapy (HNR) history. The X2 test and multinomial logistic regression were used for statistical analysis (SPSS 20.0, p < 0.05). Results: Among 1831 patients, OM was showed in 750 in any grade (41%), during cetuximab treatment. Most patients were female (n=944, 51.6%), <70years-old (n=1149, 62.8%), had larynx cancer (n=789, 43.1%) in T4 (n=579, 47.7%), N0 (n=509, 52.6%) stages. Primary tumor surgery was performed in 1476 (80.6%) patients, radiotherapy in 606 (33.1%) patients and cetuximab protocols most used involved up to four cycles (n=1072, 58.5%) of <400mg (n=996, 54.4%) cetuximab doses. Female (OR [odds ratio] = 2.17, CI95% = 1.26-3.75), >70 years-old patients (OR = 16.02, CI95% = 11.99-21.41), with HHNR (OR = 1.84, 1.41-2.40), treated with >4 cycles (OR = 1.52, CI95% = 1.16-2.01) and high doses of cetuximab (OR = 3.80, CI95% = 2.52-5.71) are the greatest risk factors for OM. Conclusions: Since the clinical benefit of cetuximab in the treatment of older patients is limited and there is a high OM, especially in women with head and neck treated with radiotherapy, high doses and a high number of cetuximab cycles must be administered with caution. (AU)
Descriptores:	estomatitis cetuximab farmacoterapia sexo adenolinfoma neoplasias de cabeza y cuello radioterapia
Límites:	seres humanos
Tipo de Publicación:	estudio comparativo
Responsable:	ES15.1 - BNCS

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Id:	231228
Autor:	Aravena Salazar, Juan Pablo; Matus Miranda , Gustavo; Dethlefs Canto, Jessika; Niklander, Sven Eric.
Título:	New complementary alternatives in third molar autotransplantation: A systematic review
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e241-e247, Mar. 2024. tab, graf.
Idioma:	en.
doi:	10.4317/medoral.26233.
Resumen:	Background: Dental autotransplantation (DAT) is defined as the replacement or direct transfer of an impacted, semi-impacted or erupted tooth to a donor site, either to a post-extraction socket or to a surgically created socket within the same individual. The use of new technological advances, such as 3-D dental models based on computer-aided design, among others, have been reported to improve the success rate of DAT. Therefore, we aimed to perform a systematic review to explore the possible benefits that the use of these innovative techniques can provide when applied to DAT. Material and Methods: The literature search was conducted in PubMed, Scopus, and Web of Science databases following the PRISMA guidelines. The research question was: "Are computerized technological advancements a useful tool for improving the success of third molar autotransplantation technique? Results: The initial literature search identified 195 articles, of which only 11 were included for qualitative analysis. All studies used 3D dental models based on computer-aided design data. Surgical guides and stereolithographic models were used by 4 and 1 study respectively. A total of 91 transplanted teeth were evaluated, out of which only 88 were considered within the parameters of clinical success (96.7%). Only 7 out of the 11 articles reported the specific autotransplanted tooth, being mandibular third molars the most prevalent autotransplanted teeth. Conclusions: Although the application of new technologies for DAT increases the success rate of this technique, further primary studies are still needed to address long-term teeth survival rates and complications. The cost and availability to implement the integration of these techniques to DAT may be a variable to consider, as this can be a limitation for some patients or for low-income countries. (AU)
Descriptores:	alveolo dental intervenciones quirúrgicas modelos dentales pacientes IMAGENOLOGIA TRIDIMENSIONAL
	-revisiones sistemáticas como asunto
Límites:	seres humanos
Tipo de Publicación:	estudio comparativo
Responsable:	ES15.1 - BNCS

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Id:	231227
Autor:	Rios Gonzalez, Sebastian; Heredero Jung, Susana; Ruiz Masera, Juan Jose; Martínez Sahuquillo Marquez, Angel.
Título:	Quality of life and functional outcomes in tongue cancer patients: a long-term, prospective, comparative study
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e232-e240, Mar. 2024. tab, graf.
Idioma:	en.
doi:	10.4317/medoral.26228.
Resumen:	Background: The tongue has an indispensable role in communication, swallowing and breathing. Tongue cancer treatment involves direct resection of the tumor and surrounding tissue, which can limit many essential functions of the tongue. There are few patient-reported quality of life studies involving tongue cancer exclusively. There is also a lack of data on the outcomes of quality of life regarding different reconstructive methods, adjuvant nonsurgical therapies and other predicting factors. Our objective is to assess the quality of life, functional status, and predicting factors in patients with tongue cancer up to one year after surgical resection. Material and Methods: Thirty-six patients with tongue cancer were prospectively identified between October of 2017 and January 2021. Patients were examined before and one, three, six and twelve months after surgical resection with the validated University of Washington Quality of Life questionnaire (UW-QOL). Data collection included patient age, sex, TNM staging, size of resection, neck dissection, tracheostomy, reconstructive method and adjuvant therapies. Outcome scores were compared using the Friedman test. Multiple linear regression analysis was used to identify the predictors of quality of life and functional status. Results: The use of UWQOL scores as dependent variables revealed the following predicting factors: age, tobacco use, radiotherapy, chemotherapy, reconstruction method and neck dissection. Conclusions: The most relevant findings in our study are that flap reconstruction becomes increasingly necessary when a glossectomy resection is over 45 mm, in order to maintain tongue function. We established that the reconstructive flap type does not influence quality of life in the long term. Also, we have found that cervical sentinel node biopsy provides better quality of life over neck dissection in the first 3 months after surgery. (AU)
Descriptores:	neoplasias de la lengua calidad de vida traqueotomía INTERVENCIONES DE CIRUGIA PLASTICA tratamientos complementarios ESTADO FUNCIONAL radioterapia farmacoterapia tabaco
	-terapéutica
Límites:	seres humanos
Tipo de Publicación:	estudio comparativo
Responsable:	ES15.1 - BNCS

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Id:	231226
Autor:	Recchioni, Christian; Junior, Emyr Stringhini; Cama Ramacciato, Juliana; Butini Oliveira, Luciana.
Título:	Oral maxillofacial surgeons and Orthodontists' perceptions about anterior inferior crowding and indications of mandibular third molar extraction / Percepciones de los cirujanos maxilofaciales y ortodoncistas sobre el apiñamiento anteroinferior y las indicaciones de la extracción del tercer molar mandibular
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e227-e231, Mar. 2024. tab.
Idioma:	en.
doi:	10.4317/medoral.26218.
Resumen:	Background: There are still many doubts about anterior inferior crowding and indications of mandibular third molar extraction, although it is very studied subject in the literature. The aim of this study was to evaluate the perceptions of oral maxillofacial surgeons (OMFSs) and orthodontists about anterior inferior crowding and indications of mandibular third molar extraction. Material and Methods: A web-based survey was developed and sent to professionals in order to collect their opinion about the fact that third lower molars cause crowding and questions about the indication of third molars for orthodontic treatment. Descriptive analysis was performed and Chi-square or G tests were applied with a 95% confidence interval. Results: The study included a total of 218 participants, of whom 115 were OMFSs and 103 were orthodontists. The results showed that 56.5% of OMFSs and 35.0% of orthodontists believe that the lower third molars cause anterior inferior crowding (p<0.001). A total of 91.3% of OMFSs and 70.9% of orthodontists indicate the extraction of lower third molars to aid orthodontic treatment (p<0.001). Conclusions: It can be concluded that in being an oral maxillofacial surgeon, a higher odds ratio is observed to consider that lower third molars cause dental crowding compared to those who are orthodontist. The indication of exodontia of lower third molars for orthodontic treatment was more frequent among OMFSs when compared to orthodontists.(AU)
Descriptores:	tercer molar/cirugía ortodoncistas Cirujanos orales y maxilofaciales extracción dental maloclusión/cirugía
	-medicina oral patología bucal salud bucal cirugía oral encuestas y cuestionarios
Límites:	seres humanos masculino femenino
Responsable:	ES15.1 - BNCS

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Id:	231225
Autor:	Siripornkitti, Wachiravit; Pengpis, Nawaporn; Chanswangphuwana, Chantiya; Prueksrisakul, Titipong.
Título:	Therapeutic response of oral chronic graft-versus-host disease to topical corticosteroids according to the 2014 National Institutes of Health (USA) consensus criteria / Respuesta terapéutica de la enfermedad de injerto contra huésped crónica oral a los corticosteroides tópicos según los criterios de consenso de los Institutos Nacionales de Salud (EE. UU.) de 2014
Fuente:	Med. oral patol. oral cir. bucal (Internet);29(2):e219-e226, Mar. 2024. tab, graf, ilus.
Idioma:	en.
doi:	10.4317/medoral.26203.
Resumen:	Background: Chronic graft-versus-host-disease (cGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. The oral cavity is one of the most frequently affected anatomic sites and is affected in 70% of all patients who develop cGVHD. The objective of this study was to determine the therapeutic response to topical corticosteroids and clinical outcome of patients with oral cGVHD using the 2014 NIH consensus criteria. Material and Methods: The oral manifestations of cGVHD were collected at the first and the follow-up (FU) visits after the therapeutic treatment of oral GVHD. The FU intervals were: FU0, first visit; FU1, 0-1 month; FU2, 1-3 months; FU3, 3-6 months; FU4, 6-9 months; and FU5, 9-12 months. The oral cGVHD activity was assessed using the NIH modification of the Schubert Oral Mucosa Rating Scale (OMRS) and Thongprasom sign score. The functional impact was assessed by the organ-specific severity score. Results: Fourteen patients (93.3%) at FU0 were being treated with at least one form of systemic immunosuppressive therapy, i.e., prednisolone, cyclosporin, and tacrolimus. The OMRS was reduced between FU0 and FU3 (p < 0.001), FU0 and FU4 (p < 0.001), and FU0 and FU5 (p = 0.004). The organ-specific severity scores were also reduced between FU0 and FU4 (p = 0.016), and FU0 and FU5 (p = 0.001). There was no significant difference in the highest Thongprasom sign score between all follow-up intervals (FU0-FU5) (p = 0.201). One patient (6.7%) at FU4 and three patients (20.0%) at FU5 did not receive topical corticosteroid therapy for oral cGVHD....(AU)
Descriptores:	enfermedad injerto contra huésped hormonas de la corteza suprarrenal trasplante de células madre hematopoyéticas glucocorticoides/uso terapéutico SINDROME DE BRONQUIOLITIS OBLITERANTE
	-medicina oral salud bucal patología bucal Estados Unidos NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH, U.S.
Límites:	seres humanos masculino femenino
Responsable:	ES15.1 - BNCS

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