Base de datos : IBECS
Búsqueda : "Allergol. immunopatol" [Revista]
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  1 / 1563 IBECS  
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Id: ET2-3862 IBECS-Express
Autor: Dos Santos, Stephanie Campos; Konstantyner, Tulio; Cocco, Renata Rodrigues.
Título: Effects of probiotics in the treatment of food hypersensitivity in children: a systematic review
Fuente: Allergol. immunopatol;48(1):95-104, ene.-feb. 2020. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2019.04.009.
Resumen: Introduction: Food allergy is considered a public health problem for children. The modulation of the intestinal microbiota seems a promising strategy for the control of allergic reactions. Objective: To describe the effects of different forms of probiotics in pediatric food hypersensitivity treatment. Data source: We conducted a systematic review based on clinical trials published in the PubMed and Web of Science databases. The searches were carried out using the MeSH terms "Food Hypersensitivity", "Probiotics," "Lactobacillus", and "Bifidobacterium". Data synthesis: The final selection resulted in 18 clinical trials, which were predominantly samples of infants and pre-school children. The most-often used strain, either alone or in combination, was Lactobacillus rhamnosus GG; a placebo was mainly used in the control group. As for the vehicle, the most common forms were capsules and infant formulas, and the period of intervention ranged from four weeks to 24 months, with weekly or monthly visits to measure the outcomes. In these 18 trials, 46 analyses were performed with 27 different types of outcomes to evaluate the effects of probiotics (12 laboratory and 15 clinical). Twenty-seven of these analyses demonstrated the benefits of using these microorganisms. The SCORAD (atopic dermatitis index) and IgE levels and cytokines were the outcomes mostly evaluated. Conclusion: The use of probiotics is beneficial in promoting immunomodulation and reducing clinical symptoms. However, more methodologically based research is needed to clarify the effect from each type, dose, and time of using them for the establishment of definitive care protocols

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  2 / 1563 IBECS  
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Id: ET2-3861 IBECS-Express
Autor: Moghtaderi, M; Ashraf, MA; Teshnizi, SH; Nabavizadeh, H; Farjadian, S; Fereidouni, M.
Título: The level of allergens in dust samples collected from selected schools in Shiraz, Iran and its asthma-risk implications
Fuente: Allergol. immunopatol;48(1):90-94, ene.-feb. 2020. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2019.05.005.
Resumen: Background: Both home and school are important places where children are exposed to various indoor allergens. This study aimed to identify the profile of indoor allergens in schools and its impact on asthma development. Methods: A total of 104 classrooms from 52 schools were selected for dust collection during the fall of 2017. The levels of indoor allergens including dust mite (Der f1, Der p1), cat (Fel d1), cockroach (Bla g1) and mouse (Mus m1) were measured by enzyme linked immunosorbent assay (ELISA). The diagnosis of asthma was made in all students of the selected classes by the allergist. The collected data were analyzed using SPSS version 21.0. Results: Out of 2816 students in the selected classes, 180 students were involved with asthma. Students were mostly exposed to Bla g1 (83.1%), followed by Der f1 (51.5%), Mus m 1 (45.5%), Der p1 (8.9%) and Fel d1 (7.9%) in the dust collected from 101 classrooms. Although levels of all studied allergens in the settled dust of the classrooms were low, there was a relationship between Fel d1 in the classroom dust and development of asthma. Conclusion: This study showed considerable levels of cockroach allergens in schools. Exposure to cat allergen in our schools played an important role in asthma development; further school-based investigations require evaluating the role of classroom allergen on asthma development

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  3 / 1563 IBECS  
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Id: ET2-3860 IBECS-Express
Autor: Guo, Y; Yu, L; Deng, Y; Ke, H-J; Wu, J-L.
Título: Associations between serum 25-hydroxyvitamin D levels and allergic sensitization in early childhood
Fuente: Allergol. immunopatol;48(1):84-89, ene.-feb. 2020. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2019.06.016.
Resumen: Background and objectives: Vitamin D status may be related to allergen sensitizations, but the evidence is inconsistent. The objective of this study was to assess whether serum 25-hydroxyvitamin D (25(OH)D) levels were associated with allergic sensitizations in early childhood. Methods: Data were collected from 2642 children who visited the Guangdong Women and Children's Hospital from January 2016 to May 2017 for routine health check-ups. Serum 25(OH)D levels were tested by electrochemiluminescence immunoassay. Allergic sensitizations including food and inhalant allergens were tested for specific IgE antibodies at one year (12 months 0 days through 12 months 30 days) and two years (24 months 0 days through 24 months 30 days) of age. Results: The mean level of serum 25(OH)D was 86.47 ± 27.55 nmol/L, with a high prevalence of vitamin D insufficiency (< 75 nmol/L) in children aged 0-2 years (36.8%). Lower 25(OH)D levels with serum total IgE of more than 200IU/mL (81.54 ± 25.53 nmol/L) compared with less than 100 IU/mL (87.92 ± 28.05 nmol/L). The common sensitization to allergens in children aged one and two years were milk (44.2%), cat epithelium (26.4%), egg (13.1%), dog epithelium (12.7%) and Dermatophagoides farinae (6.7%). After multivariate adjustment, data in 25(OH)D treated as a continuous variable or categories, no consistent associations were found between 25(OH)D levels and allergen-specific IgEs. Conclusions: Serum 25(OH)D level showed an inverse relationship with total IgE level in early childhood. However, there is lack of evidence to support associations between low 25(OH)D levels and allergic sensitization to various allergens

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  4 / 1563 IBECS  
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Id: ET2-3859 IBECS-Express
Autor: Guvenir, H; Dibek Misirlioglu, E; Buyuktiryaki, B; Zabun, MM; Capanoglu, M; Toyran, M; Civelek, E; Kocabas, CN.
Título: Frequency and clinical features of pollen-food syndrome in children
Fuente: Allergol. immunopatol;48(1):78-83, ene.-feb. 2020. tab.
Idioma: en.
doi: 10.1016/j.aller.2019.07.010.
Resumen: Background: Pollen-food syndrome (PFS) is an allergic reaction to fresh fruits, vegetables and/or nuts that can occur in patients who are allergic to pollen. The prevalence of PFS in children is not clearly known. Objective: The objective of this study was to determine the frequency and clinical features of PFS in pediatric patients with pollen-induced allergic rhinitis (AR). Method: This study was conducted in the pediatric allergy outpatient clinic of our hospital. Pollen-induced seasonal AR patients who were evaluated for any symptoms appearing after consuming any fresh fruits and vegetables. Results: Six hundred and seventy-two pollen-sensitized patients were included in this study. The symptoms related to PFS were reported in 22 (3.3%) patients. The median age of the patients was 12.3 years and 59% (n = 13) were female. Peach was the most common culprit (22%). There were isolated oropharyngeal symptoms in 20 (91%) patients and anaphylaxis in two (9%) patients with the suspected food. The multiple logistic regression analysis revealed that female gender, history of atopic dermatitis and allergic diseases in the family were the potential risk factors for PFS [Odds ratio 95% CI: 3.367 (1.344-8.435), 5.120 (1.935-13.550), 3.046 (1.239-7.492), respectively]. Conclusion: PFS can be seen in children who are followed up for pollen-induced AR. The symptoms of PFS are usually mild and transient. However, comprehensive evaluation of patients is important since serious systemic reactions such as anaphylaxis can also be observed

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  5 / 1563 IBECS  
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Id: ET2-3858 IBECS-Express
Autor: Zejda, JE; Beridze, V; Bakhtadze, T; Beridze, S; Abuladze, L; Partenadze, N; Lawson, J.
Título: Prevalence of and factors associated with underdiagnosis of pediatric asthma in Batumi, Georgia
Fuente: Allergol. immunopatol;48(1):73-77, ene.-feb. 2020. tab.
Idioma: en.
doi: 10.1016/j.aller.2019.05.006.
Resumen: Background and objective: A recent survey in Batumi, Georgia showed a low prevalence of asthma in children (1.8%). A potential explanation is underdiagnosis of asthma. To investigate this, we conducted a follow up to the survey with the objective of estimating the level of childhood asthma underdiagnosis and to describe factors related to it. Methods: Subjects included 437 survey participants who had a history of asthma-like symptoms and no diagnosis of asthma. All children underwent clinical examination (spirometry, skin prick tests, FeNO measurement) to identify new cases of asthma. The distribution of host and environmental factors was compared between the group with newly identified asthma and a group of 59 children with previously known asthma (diagnosed asthma). Results: Clinical investigation identified 107 cases of undiagnosed asthma. The corrected asthma prevalence estimate was 5.1% (95%CI: 4.4%-5.9%) suggesting that 65% of asthma cases were undiagnosed. Compared to children with diagnosed asthma, children with undiagnosed asthma were younger (8.2 ± 1.6 vs. 9.3 ± 2.1; p = 0.0005), had less frequent history of allergic disorders (38.3% vs. 64.4%; p = 0.001), and a lower prevalence of parental asthma (1.8% vs. 8.4%; p = 0.04). The groups did not differ in terms of environmental characteristics except for more exposure to passive smoking in the undiagnosed asthma group (p = 0.01). Multivariate analysis confirmed results of simple analyses. Conclusion: In Batumi, 65% of children with asthma remain undiagnosed. Older age of a child, coexisting allergic disorders, and parental asthma seem to facilitate diagnosis. Implementation of current diagnostic guidelines should improve diagnostic accuracy of pediatric asthma in Batumi

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  6 / 1563 IBECS  
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Id: ET2-3857 IBECS-Express
Autor: Woicka-Kolejwa, Katarzyna; Jerzynska, Joanna; Majak, Pawel; Koniarek, Agnieszka; Stelmach, Iwona.
Título: Glycoprotein A (GARP) in children who outgrow food allergy
Fuente: Allergol. immunopatol;48(1):67-72, ene.-feb. 2020. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2019.06.008.
Resumen: Background: There is little understanding of the mechanisms by which food allergy (FA) develops into persistent disease, or by which symptoms it regresses. Food allergy is a major health problem in developed countries, where the prevalence reaches up to 6% in children and 3% in the adult population. Objective: Children with food allergy remission (FAR) and those without FAR below five years of age, were compared 7-10 years with respect to clinical data and expression of glycoprotein A repetitions predominant (GARP) on peripheral blood mononuclear cells. Methods: Forty children with FAR and 40 children without FAR at age 7-10, in whom FA was previously diagnosed at age below five years were evaluated. In this prospective study, demographic and clinical data were taken, patients were classified as atopic based on history and serum specific IgE (sIgE) for a specific allergen. Blood samples were obtained from all patients to assess expression of GARP. Results: We observed higher expression of GARP in children with FAR compared to children without FA (p = 0.005); optimal cut-off for GARP prediction of the remission was 20.1%. Children with FAR and food-specific IgE in serum had higher expression of GARP compared to children with low food specific IgE (< 0.35 kU/L). Keeping pets at home decreased, and presence of allergic rhinitis increased ORs for high expression of GARP (hGARP) in our patients. Conclusion: hGARP (>20.1%) is related with FAR in school children. Allergic rhinitis, and pets at home modify this effect of GARP. Children with allergic rhinitis have less chance of developing remission despite maintaining immune tolerance (hGARP); quite the opposite case with pets at home

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  7 / 1563 IBECS  
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Id: ET2-3856 IBECS-Express
Autor: Rezaei, A; Harsini, S; Sadr, M; Ziaee, V; Rezaei, N.
Título: Interleukin-23 receptor gene polymorphisms in Iranian patients with juvenile systemic lupus erythematosus
Fuente: Allergol. immunopatol;48(1):62-66, ene.-feb. 2020. tab.
Idioma: en.
doi: 10.1016/j.aller.2019.05.007.
Resumen: Introduction and objectives: Considering the possible roles of interleukin-23 receptor (IL-23R) gene in the pathogenesis of juvenile systemic lupus erythematosus (JSLE), the objective of this study was to elucidate whether polymorphisms of the IL23R are associated with susceptibility to JSLE in an Iranian population. Materials and methods: A case-control study on 62 patients with JSLE and 78 healthy controls was performed to investigate the associations of four single nucleotide polymorphisms (SNPs) in IL-23R gene, namely, rs7517847, rs10489629, rs11209026, and rs1343151, with susceptibility to JSLE, using real-time polymerase chain reaction Taqman genotyping technique. Results: Analysis of allele and genotype frequency of four selected SNPs revealed statistically significant positive association between homozygous variant of rs7517847 (TT) (P, 0.02) and T allele at the same position (P, 0.01) with JSLE vulnerability. There was no significant association between other evaluated SNPs and JSLE susceptibility. Conclusion: These findings suggest that particular IL-23R gene variants could affect individual susceptibility to JSLE

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  8 / 1563 IBECS  
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Id: ET2-3855 IBECS-Express
Autor: Rodriguez-Martinez, CE; Sossa-Briceño, MP; Castro-Rodriguez, JA.
Título: Direct medical costs of RSV-related bronchiolitis hospitalizations in a middle-income tropical country
Fuente: Allergol. immunopatol;48(1):56-61, ene.-feb. 2020. tab.
Idioma: en.
doi: 10.1016/j.aller.2019.04.004.
Resumen: Introduction and objectives: With the objective of making informed decisions on resource allocation, there is a critical need for studies that provide accurate information on hospital costs for treating respiratory syncytial virus (RSV)-related bronchiolitis, mainly in middle-income countries (MICs). The aim of the present study was to evaluate the direct medical costs associated with bronchiolitis hospitalizations caused by infection with RSV in Bogota, Colombia. Material and methods: We reviewed the available electronic medical records (EMRs) for all infants younger than two years of age who were admitted to the Fundacion Hospital de La Misericordia with a discharge principal diagnosis of RSV-related bronchiolitis over a 24-month period from January 2016 to December 2017. Direct medical costs of RSV-related bronchiolitis were retrospectively collected by dividing the infants into three groups: those requiring admission to the pediatric ward (PW) only, those requiring admission to the pediatric intermediate care unit (PIMC), and those requiring to the pediatric intensive care unit (PICU). Results: A total of 89 patients with a median (IQR) age of 7.1 (3.1-12.2) months were analyzed of whom 20 (56.2%) were males. Overall, the median (IQR) cost of infants treated in the PW, in the PIMC, and in the PICU was US$518.0 (217.0-768.9) vs. 1305.2 (1051.4-1492.2) vs. 2749.7 (1372.7-4159.9), respectively, with this difference being statistically significant (p < 0.001). Conclusions: The present study helps to further our understanding of the economic burden of RSV-related bronchiolitis hospitalizations among infants of under two years of age in a middle-income tropical country

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  9 / 1563 IBECS  
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Id: ET2-3854 IBECS-Express
Autor: Kara, M; Beser, OF; Konukoglu, D; Cokugras, H; Erkan, T; Kutlu, T; Cokugras, FC.
Título: The utility of TNF-alfa, IL-6 and IL-10 in the diagnosis and/or follow-up food allergy
Fuente: Allergol. immunopatol;48(1):48-55, ene.-feb. 2020. graf, tab.
Idioma: en.
doi: 10.1016/j.aller.2019.04.011.
Resumen: Background: Several pro-inflammatory and anti-inflammatory mediators play a role in the immunopathogenesis of food allergy (FA). The aim of this study was to investigate the utility of serum biomarkers like interleukin (IL)-10, TNF-alfa, and IL-6 in the diagnosis and/or follow-up of FA. Methods: Sixty (25 females, 41.6%) newly diagnosed FA patients [IgE mediated (group-1, n = 37), non-IgE (group-2, n = 23)] with a median age of nine (1-33) months were enrolled. Twenty-four healthy children with a median age of eight (1-36) months constituted the control group (CG). In all the subjects, serum TNF-alfa, IL-6 and IL-10 levels were evaluated at the time of diagnosis and reassessed four weeks after therapeutic elimination diet (TED). Results: The mean white blood cell count and median absolute eosinophile count of the CG were significantly lower than group-1 (p values were 0.019 and 0.006, respectively). The mean absolute neutrophile count and the median IL-6 were significantly higher in group-1 when compared with group-2 (p values were 0.005 and 0.032, respectively. Median TNF-alfa and IL-6 levels were significantly higher in the pre-TED among all patients (p values were 0.005 and 0.018, respectively). In group-1, median TNF-α and IL-6 levels decreased significantly after TED (p values were 0.01 and 0.029, respectively). Conclusions: Our findings support the role of inflammation in the pathogenesis of FA. Serum TNF-alfa and IL-6 levels may be useful markers for follow-up in FA, especially among IgE-mediated FA patients. Evaluation of IL-10 results was not sufficient for an interpretation of clinical tolerance

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  10 / 1563 IBECS  
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Id: ET2-3853 IBECS-Express
Autor: Teijeiro, A; Cuello, MN; Raiden, MG; Vieyra, RE; Solé, D; Ellwood, P; Gomez, RM.
Título: The relationship between second-hand smoke and wheezing in infants from Córdoba, Argentina
Fuente: Allergol. immunopatol;48(1):42-47, ene.-feb. 2020. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2019.06.010.
Resumen: Background: Wheezing constitutes a common respiratory symptom in children, and several risk factors have been associated with the prevalence of recurrent wheezing (RW) and its severity, especially viral respiratory infections and second-hand smoke (SHS) exposure. Objective: To analyze the relationship between smoking patterns in the home and wheezing, in infants from the city of Córdoba, Argentina, during their first year of life. Methods: Parents of infants were invited to complete a standardized questionnaire voluntarily and anonymously (WQ-P1-EISL). Wheezing in the first 12 months of life was classified as occasional wheezing (OW) when having one or two episodes during the first 12 months of life; recurrent wheezing (RW) if having three or more, and more frequent wheezing (MFW) ≥ 6 episodes. Results: 409 infants (39.0%) had one or more episodes of wheezing in the first 12 months. Of these, 214 infants (52.3%) presented occasional wheezing (OW), 135 (33%) had recurrent wheezing (RW), and 60 (14.7%) more frequent wheezing (MFW). SHS was significantly related to MFW, especially if the mother smoked (OR = 2.7; IC 95%: 1.4-5.18; p = 0.0009) or if she smoked during pregnancy (OR = 4; IC 95%: 1.8-8.5; p = 0.0001). This group of MFW was also associated with SHS as well as having been to the emergency room for wheezing (40.87%, p = 0.0056). Conclusion: The results indicate that second-hand tobacco smoke is a significant risk factor for the presence of wheezing in infants, and for its severity. Our findings have significant implications for public health, as smoking is a modifiable behavior

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