Base de datos : IBECS
Búsqueda : "Allergol. immunopatol" [Revista]
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  1 / 1593 IBECS  
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Id: ET2-5493 IBECS-Express
Autor: Guo, X; Cheng, L; Yang, S; Che, H.
Título: Pro-inflammatory immunological effects of adipose tissue and risk of food allergy in obesity: Focus on immunological mechanisms
Fuente: Allergol. immunopatol;48(3):306-312, mayo-jun. 2020. ilus.
Idioma: en.
doi: 10.1016/j.aller.2019.06.004.
Resumen: Over the past three decades, the number of obese people has risen steadily. The chronic low-grade inflammatory state and the non-specific activation of the immune system have contributed greatly to the development of obesity-related immunology. Food allergy as a kind of inflammatory disease with abnormal immune response may be associated with obesity. This review begins with the pro-inflammatory immunological effects of adipose tissue in obesity, and explains the possible effects of obesity on food allergy. In short, obesity not only directly causes imbalance of allergic-related immune cells in adipose tissue, but also indirectly causes this consequence through affecting expression of adipocytokines and peroxisome proliferator-activated receptor gamma (PPARγ) in adipose tissue. As a result, circulating levels of pro-inflammatory factors which are partly derived from adipose tissue increase, which might cause intestinal barrier injury. Therefore, obesity may increase the risk of food allergy

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  2 / 1593 IBECS  
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Id: ET2-5492 IBECS-Express
Autor: Scheffer-Mendoza, S; Espinosa-Padilla, SE; López-Herrera, G; Mujica-Guzmán, F; López-Padilla, MG; Berrón-Ruiz, L.
Título: Reference values of leukocyte and lymphocytes populations in umbilical cord and capillary blood in healthy Mexican newborns
Fuente: Allergol. immunopatol;48(3):295-305, mayo-jun. 2020. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2019.12.009.
Resumen: INTRODUCTION: In newborns, dramatic changes occur in the blood and bone marrow during the first hours; there are rapid fluctuations in the quantities of leukocytes populations. In this work, we investigated leukocytes subsets counts in two types of blood samples (cord blood and capillary blood) extracted from healthy newborns. METHODS: Blood samples from Mexican neonates were collected by Instituto Nacional de Pediatría with written informed consent. For all samples we determined leukocytes populations; neutrophils, monocytes, total lymphocytes, and populations: T CD3+ cells, TCD4+ cells, T CD8+ cells, B CD19+ cells and NK CD16+56 cells by flow cytometry. We used the Mann-Whitney U test to compare leukocytes of cord and capillary blood; also to analyze the differences between gender and we obtained reference values of the cord and capillary blood in neonates. RESULTS: We observed higher absolute counts and frequencies of total lymphocyte in capillary blood compared with cord blood. In absolute numbers, the capillary blood showed significant differences in neutrophils, monocytes, lymphocytes, T CD3+ cells, T CD4+ cells, T CD8+ cells, B CD19+ cells, and NK cells; no significant differences were observed between genders. DISCUSSION: Our data contribute to newborn Mexican reference values for all these populations of leukocytes. We found that the dispersal range differs between the two types of blood, suggesting a different fate in the immune response. Immunophenotyping of the blood cell population to identify these cells is an essential tool in the diagnosis and follow-up of neonates with immunodeficiencies and other immune disorders

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  3 / 1593 IBECS  
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Id: ET2-5491 IBECS-Express
Autor: Karaman, S; Turedi, B.
Título: Neutrophil-lymphocyte ratio: a possible marker of remission in children with chronic spontaneous urticaria
Fuente: Allergol. immunopatol;48(3):290-294, mayo-jun. 2020. tab.
Idioma: en.
doi: 10.1016/j.aller.2019.11.007.
Resumen: BACKGROUND: Chronic spontaneous urticaria (CSU) is a disease that seriously disturbs the quality of life of the patient. Currently there is no prognostic marker of the disease. Our aim in this study was to determine possible prognostic markers of CSU in children. METHOD: All patients younger than 18 years of age who were followed by the Pediatric Immunology and Allergy Clinic of Diyarbakir Children's Hospital with a diagnosis of CSU between June 2017 and February 2019 were included in the study. Clinical and laboratory findings were compared between the symptomatic patient group and the patient group that remained in remission for at least three months without use of medication. RESULTS: Of the 52 cases included in the study, 32 (61.5%) were male. Mean age at time of diagnosis was 9.4 ± 4.4 years. Twenty-four cases (46.2%) went into remission. Young age at the time of diagnosis and being in the initial months of the disease were found to be associated with good prognosis (p < 0.05). Among laboratory results, elevation in absolute neutrophil count and neutrophil/lymphocyte ratio (NLR) were found to be associated with poor prognosis (p < 0.05). NLR was positively correlated with disease duration (p < 0.05). CONCLUSIÓN: For childhood CSU, younger age and initial months of the disease are good prognostic indicators, while only neutrophil/lymphocyte count can be used as a remission marker

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  4 / 1593 IBECS  
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Id: ET2-5490 IBECS-Express
Autor: Arrais, Margarete; Lulua, Ofélia; Quifica, Francisca; Rosado-Pinto, José; Gama, Jorge MR; Brito, Miguel; Taborda-Barata, Luis.
Título: Sensitisation to aeroallergens in relation to asthma and other allergic diseases in Angolan children: a cross-sectional study
Fuente: Allergol. immunopatol;48(3):281-289, mayo-jun. 2020. tab.
Idioma: en.
doi: 10.1016/j.aller.2019.10.005.
Resumen: INTRODUCTION AND OBJECTIVES: In Africa, few studies of sensitisation profiles have been performed in children or adolescents and, in Angola, there are none. The objectives of the present study were to assess the sensitisation profile of Angolan schoolchildren and to determine the relationship between that pattern, sociodemographic factors, asthma and other allergic diseases. MATERIALS AND METHODS: Cross-sectional, observational study in 5-14-year-old children, performed between September and November 2017, in the Province of Bengo, Angola. Five schools (15%) were randomly selected in the geographical area of the study: three from an urban area, and two from a rural area. Data were collected using the Portuguese versions of the ISAAC questionnaires for children and adolescents, regarding asthma, rhinitis and eczema. Skin prick tests (SPT) were performed with a battery of 12 aeroallergens. Stools were assessed for the presence of helminths. Descriptive statistics were used, as well as univariate calculation of odds ratios. RESULTS: Sensitisation to aeroallergens was low (8%) and most sensitised children were asymptomatic. Most frequent sensitisations involved house dust mites, cockroach or fungi, and a high proportion of children (78.1%) were monosensitised. No relationship was detected between sensitisations and asthma, rhinitis or eczema. Place of residence, gender, age or helminthic infection did not affect the probability of having positive SPTs. CONCLUSIONS: The most frequent sensitisations in children from Bengo Province in Angola involve house dust mites, followed by cockroach and fungi. No relationship was found between atopic sensitisation and asthma or other allergic diseases

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  5 / 1593 IBECS  
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Id: ET2-5489 IBECS-Express
Autor: Dos Santos, Karoliny; Traebert, Jefferson; Piovezan, Anna Paula; Da Silva, Jane.
Título: Relevance of the first thousand days of life to the development of wheezing in children aged 6-7 years
Fuente: Allergol. immunopatol;48(3):270-280, mayo-jun. 2020. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2019.12.007.
Resumen: INTRODUCTION: The first thousand days of life are a critical stage for the development of respiratory and immune systems. Many events in this period may be associated with wheezing in childhood. OBJECTIVE: This study aimed to investigate the association between early life determinants and wheezing in children aged 6-7 years. MATERIALS AND METHODS: Population-based case-control study using early-life related questions. We used the International Study of Asthma and Allergies in Childhood questionnaire to assess wheezing symptoms. Multiple logistic regressions were performed according to a hierarchical framework, considering the complex dynamic of wheezing/asthma and potential interaction between different levels of determination. RESULTS: A total of 820 children were included, from which 162 reported wheezing symptoms (19.7%). Multivariable analysis identified socioeconomic conditions (OR 2.08, 95% CI 1.08-4.00), family history of asthma (OR 2.28, 95% CI 1.37-3.75), vaginal discharge that required treatment during pregnancy (OR 1.68, 95% CI 1.00-2.83), neonatal hyperbilirubinemia (OR 2.00, 95% CI 1.17-3.42), anemia and intestinal parasitosis in the first two years (OR 2.28, 95% CI 1.22-4.25; OR 1.72, 95% CI 1.02-2.92, respectively) independently associated to wheezing at 6-7 years. Intended pregnancy was associated with reduced wheezing (OR 0.47, 95% CI 0.28-0.77). CONCLUSIONS: Several factors were associated with wheezing in childhood. Considering that intended pregnancy reduced wheezing and other associated exposures are considered modifiable, these findings may guide the planning of strategies to decrease the susceptibility to asthma symptoms in childhood

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  6 / 1593 IBECS  
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Id: ET2-5488 IBECS-Express
Autor: Moghtaderi, Mozhgan; Hesamedin Nabavizadeh, Seyed; Teshnizi, Saeed Hosseini.
Título: The frequency of cross-reactivity with various avian eggs among children with hen's egg allergy using skin prick test RESULTS: fewer sensitizations with pigeon and goose egg
Fuente: Allergol. immunopatol;48(3):265-269, mayo-jun. 2020. graf, tab.
Idioma: en.
doi: 10.1016/j.aller.2019.10.002.
Resumen: INTRODUCTION AND OBJECTIVES: A high rate of cross-reactivity has been reported between the specific proteins of hen's egg with proteins of various avian eggs by quantitative immunoelectrophoretic techniques. The aim of this study was to assess the clinical cross-reactivity of different birds' eggs in children with hen's egg allergy based on skin prick test results. MATERIAL AND METHODS: This cross-sectional study enrolled 52 infants with hen's egg allergy and 52 healthy infants with no history of food allergy from October 2018 to April 2019. Skin prick tests were performed in both patient and control groups with fresh extract of white and yolk related to pigeon, duck, goose, turkey, quail, and partridge. RESULTS: Fifty (96.1%) children with hen's egg allergy showed positive sensitization to at least one of the avian eggs. The most frequent positive skin tests were related to quail's white (36 = 69.2%) followed by duck's white (34 = 65.5%), and sensitization was the least frequent in pigeon's yolk (23 = 44.2%). Skin tests of the control group were negative to all the tested extracts. CONCLUSIÓN: Because of fewer sensitizations to some avian eggs, further research should clarify starting oral immunotherapy with the yolk of goose and pigeon in children with hen's egg allergy

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  7 / 1593 IBECS  
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Id: ET2-5487 IBECS-Express
Autor: Pierotti, Felipe Faria; Aranda, Carolina Sanchez; Cocco, Renata Rodrigues; Sarinho, Emanuel; Sano, Flávio; Porto, Arnaldo; Rosário, Nelson; Neto, Herberto José Chong; Goudouris, Ekaterini; Moraes, Lilian Sanches; Wandalsen, Neusa Falbo; Mallozi, Márcia Carvalho; Pastorino, Antônio Carlos; Motta Franco, Jackeline; Chavarria, Maria Letícia; Borres, Magnus P; Solé, Dirceu.
Título: Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents
Fuente: Allergol. immunopatol;48(3):259-264, mayo-jun. 2020. tab.
Idioma: en.
doi: 10.1016/j.aller.2019.06.013.
Resumen: The clinical history is of importance in the investigation of allergic diseases but does have limitations. Many allergic conditions will be over-diagnosed if anamnesis alone is used for diagnostic criteria. Serum total immunoglobulin E (TIgE) quantification, as well as panels containing allergens prevalent in the studied population, may serve as screening tests and facilitate the diagnosis of allergic disease or its exclusion. We assessed the positivity of two versions of these tests, Phadiatop Europe® (PhEU) and Phadiatop Infant® (PhInf), as well as total IgE (TigE) values in patients with a medical diagnosis of allergic disease and non-allergic individuals. METHODS: A cross-sectional study performed in eleven Brazilian pediatric allergy centers with patients divided into groups according to the primary condition and a group of assessed control subjects. They were submitted to TIgE measurement and screening tests (PhEu and PhInf). RESULTS: TIgE mean serum levels were significantly higher among allergic patients, especially those with asthma/rhinitis or atopic dermatitis. The positivity of the screening tests, considering the total population, was 63.8% for PhEU and 72.6% for PhInf. These increased when we evaluated only the allergic subjects. The concordance index of the two tests was Kappa = 0.7 and higher among those of greater age. CONCLUSIONS: In the assessed population, there were significantly higher levels among those with positive screening tests and PhInf showed better performance in the identification of sensitized individuals, regardless of age. This is the first study to evaluate Phadiatop and Phadiatop Infant in the same population

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  8 / 1593 IBECS  
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Id: ET2-5486 IBECS-Express
Autor: Martín-Lázaro, J; Núñez-Orjales, R; González-Guzmán, LA; González, MT; Boquete, M; Carballada, F.
Título: Galactose-alfa-1, 3-galactose (alpha-gal) allergy: first pediatric case in a series of patients in Spain
Fuente: Allergol. immunopatol;48(3):251-258, mayo-jun. 2020. tab.
Idioma: en.
doi: 10.1016/j.aller.2019.07.004.
Resumen: INTRODUCTION AND OBJECTIVES: Allergy to galactose-α-1,3-galactose (alpha-gal) is a peculiar form of food allergy generally manifesting as an anaphylactic reaction hours after mammalian meat consumption, due to the presence of specific IgE against this oligosaccharide. In addition, immediate anaphylaxis may develop after exposure to other sources of alpha-gal, such as monoclonal antibody cetuximab, vaccines, plasma expanders or anti-snake venoms. Sensitization to alpha-gal has also been implicated in the rapid degeneration of biological valve implants, and recognized as a cause of occupational disease in cattle raisers. The implication of tick bites in this type of sensitization has been accepted by all the research groups dedicated to this disease. PATIENTS AND METHOD: The present study describes the clinical and sensitization characteristics of 39 patients diagnosed with alpha-gal allergy in the hospitals of our province (Lugo, Monforte de Lemos and Burela, Spain). RESULTS: Most patients were middle-age males. Of note, is the fact that the series includes the first pediatric patient reported in Spain to date. The predominant clinical manifestations were urticaria or delayed anaphylaxis after consumption of mammalian meat. Seventy-four percent of the patients reported having suffered a previous tick bite, and the clinical presentation of anaphylaxis was significantly more prevalent in those with a persistent local reaction following the bite than in those with no such reaction (p = 0.032). CONCLUSIONS: A review is also made of the disorder which, due to its variable clinical expression, is referred to as alpha-gal syndrome. The study concludes that a diagnosis of alpha-gal allergy should be considered in patients with urticaria-anaphylaxis of uncertain origin or manifesting after the administration of vaccines or products of bovine/porcine origin

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  9 / 1593 IBECS  
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Id: ET2-5485 IBECS-Express
Autor: Azzano, Pauline; Villard Truc, Florence; Collardeau-Frachon, Sophie; Lachaux, Alain.
Título: Children with eosinophilic esophagitis in real life: 10 years' experience with a focus on allergic management
Fuente: Allergol. immunopatol;48(3):244-250, mayo-jun. 2020. graf, tab.
Idioma: en.
doi: 10.1016/j.aller.2019.07.013.
Resumen: INTRODUCTION AND OBJECTIVES: Eosinophilic esophagitis (EoE) is frequently miss-diagnosed or overlooked for several years because of the invasiveness of investigations and the non-specificity of symptoms in childhood. Due to the lack of specific recommendations in children, its management remains very heterogeneous, especially concerning allergy testing. The aim of this study is to analyze our population and practices, in comparison with the literature, with a focus on allergic management, to harmonize and optimize our practice. MATERIAL AND METHODS: We included all children with a diagnosis of EoE at the Hospital Femme Mere Enfant, Bron, France. Data were collected via retrospective chart review. RESULTS: 108 patients were included with an average age of 9.5 years. Average delay before diagnosis was 6.65 years. Symptoms varied with age, with a predominance of vomiting (60% of patients), feeding difficulties (72%) and growth difficulties (24%) in children < 5 years, whereas older children often presented with feeding blockage (64%) and dysphagia (61%). Cough was frequent in our cohort (18.5%), especially in children < 10 years (38.5% between three and five years). The allergic background was frequent (70.3%) and 80% of our patients benefited from allergy testing. Allergy testing was particularly useful to guide therapy as elimination diet represented an effective treatment in 60% of our patients CONCLUSIONS: Allergy testing has to be harmonized to include major allergens (egg, milk, peanut, fish, wheat, and soy), including prick and patch tests. Allergy-testing based diet seemed to be the best compromise between efficiency and constraints, especially in mono-sensitized patients

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  10 / 1593 IBECS  
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Id: ET2-5484 IBECS-Express
Autor: Porto Neto, Arnaldo Carlos; Solé, Dirceu; Hirakata, Vânia; Salvador Schmid, Luiza; Klock, Caroline; Barreto, Sergio Saldanha Menna.
Título: Risk factors for asthma in schoolchildren in Southern Brazil
Fuente: Allergol. immunopatol;48(3):237-243, mayo-jun. 2020. graf, tab.
Idioma: en.
doi: 10.1016/j.aller.2019.07.003.
Resumen: BACKGROUND: Due to the high prevalence of recurrent wheezing in the pediatric population, it is important to be able to identify environmental risk factors that may affect the etiology of asthma in several regions. OBJECTIVE: to identify possible risk factors associated with asthma in children (9-12 years old) in Passo Fundo, Rio Grande do Sul, Brazil. MATERIAL AND METHODS: A total of 1003 school-age children were selected for the cross-sectional study by applying a standardized written questionnaire from the International Study of Asthma and Allergy, and a supplementary questionnaire (ISAAC phase II) was added to address personal, family and environmental factors. Of these, 125 children were excluded because they did not accept to do the skin prick test, resulting in a sample of 878. RESULTS: Independent risk factors associated with asthma were bronchiolitis before two years old [OR] = 3.11; 2.23-4.33, current rhinitis [0R] = 2.07; 1.43-3.0; sharing bedroom during the first year of life [OR] = 2.03; 1.36-3.04; atopy [OR] = 1,82; 1.26-2.50; use of paracetamol more than 12 times a year [OR] = 1.68; 1.20-2.31; use of antibiotics in the first six months of life [OR]=1,57 1;13-2.17; maternal asthma [OR] = 1.75; 1.05-2.78, having an indoor cat during the first year of life [OR] = 1.73, 1.07-2.78; premature birth [OR] = 1.60,1.02-2.50. CONCLUSIÓN: our results show that genetic backgrounds, environmental factors, premature birth, use of antibiotics before six months of life, using paracetamol once per month and the presence of co-morbidities such as rhinitis are the risk factors associated with asthma in Brazilian children

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