Base de datos : IBECS
Búsqueda : "Allergol. immunopatol" [Revista]
Referencias encontradas : 1401 [refinar]
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  1 / 1401 IBECS  
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Id: 172182
Autor: Pitrez, PM; Stein, RT.
Título: Low dose treatment of mice with bacterial extract (OM-85) for attenuation of experimental atopic asthma in mice - Reply
Fuente: Allergol. immunopatol;46(2):206-207, mar.-abr. 2018.
Idioma: en.
doi: 10.1016/j.aller.2017.06.002.
Resumen: No disponible
Descriptores: asma/tratamiento farmacológico
hipersensibilidad inmediata/tratamiento farmacológico
adyuvantes inmunitarios/farmacocinética
-modelos de enfermedad en animales
hiperreactividad bronquial/tratamiento farmacológico
eosinofilia pulmonar/tratamiento farmacológico
sustancias protectoras/farmacocinética
Límites: animales
ratones
Responsable: BNCS


  2 / 1401 IBECS  
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Id: 172181
Autor: Svitich, OA; Sobolev, VV; Gankovskaya, LV; Zhigalkina, PV; Zverev, VV.
Título: The role of regulatory RNAs (miRNAs) in asthma
Fuente: Allergol. immunopatol;46(2):201-205, mar.-abr. 2018. tab.
Idioma: en.
doi: 10.1016/j.aller.2017.09.015.
Resumen: Introduction: Recently, a great deal of attention has been paid to the investigation of regulatory functions of microRNA. Currently, many different mechanisms involved in the pathogenesis of asthma are known, but the whole picture of pathogenesis has not yet been studied. Conclusions: MicroRNAs play an important role in the regulation of many cellular processes. Undoubtedly, these regulatory molecules are involved in the pathogenesis of asthma, and therefore can be potential targets for treatment (AU)

No disponible
Descriptores: microARN/análisis
asma/fisiopatología
obstrucción de las vías aéreas/fisiopatología
-linfocitos T reguladores/inmunología
perfiles de expresión génica
Límites: humanos
Tipo de Publicación: revisión
Responsable: BNCS


  3 / 1401 IBECS  
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Id: 172180
Autor: Bahrololoomi, Z; Bemanian, MH; Ghaffourifard, R; Ahmadi, B.
Título: Effect of inhaled medication on dental caries index in asthmatic children
Fuente: Allergol. immunopatol;46(2):196-200, mar.-abr. 2018. tab.
Idioma: en.
doi: 10.1016/j.aller.2017.09.019.
Resumen: Introduction: Asthma is a chronic inflammatory disease of airways with a high prevalence among children in pre-school ages. Considering controversial results in different studies about the effect of this disease on the indices of dental caries, the aim of this study was to compare dmft (decay, missing, filling teeth) situation in asthmatic and non-asthmatic 6-12-year-old children. Methods: This was a case-control study on 46 asthmatic and 47 non-asthmatic children aged 6-12 years. In asthmatic children, the severity of disease, type and dose of the administered inhalational drug, duration of drug consumption, times and technique of drug administration, and washing the mouth after drug consumption was assessed. The index of primary teeth decay or dmft, dental plaque and gingival inflammation were recorded in both groups. Data were analysed by SPSS (ver. 22) using Student's T-test, chi-square test and linear regression. Findings: dmft in case and control groups was 5.25 ± 2.25 and 4.15 ± 3.27, respectively and the difference was not statistically significant (P = 0.062). None of the variables related to asthma affected dmft (P > 0.05). Conclusion: Suffering from asthma does not affect the risk of decay in primary teeth (AU)

No disponible
Descriptores: caries dental/etiología
asma/tratamiento farmacológico
-antiasmáticos/administración & dosificación
administración por inhalación
índice CPO
factores de riesgo
estudios de casos y controles
Límites: humanos
masculino
femenino
niño
Responsable: BNCS


  4 / 1401 IBECS  
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Id: 172179
Autor: Arikoglu, T; Batmaz, SB; Yildirim, DD; Tezol, Ö; Bozlu, G; Kuyucu, S.
Título: Asthma predictive index in relation to respiratory mechanics by impulse oscillometry in recurrent wheezers
Fuente: Allergol. immunopatol;46(2):190-195, mar.-abr. 2018. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2017.09.028.
Resumen: Background: The identification of children who will have persistent asthma has become a focus of recent research. The aim of this study was to assess whether impulse oscillometry (IOS) has a diagnostic value to predict modified API (asthma predictive index) in pre-schoolers with recurrent wheezing. Methods: Pre-school children aged 3-6 years with recurrent wheezing were enrolled. The study population was divided into two groups based on mAPI criteria. Lung function was assessed by IOS. Results: 115 children were assessed; 75 (65.2%) of them were male. The median age was 39 months (min: 36, max: 68 months). 64 (55.6%) of the children were mAPI positive. The R5-R20% levels of children with positive mAPI were significantly higher compared to negative mAPI. Also, R5-R20% levels of children with parental asthma and R20% pred and resonant frequency (Fres) levels of children with inhalant sensitization were higher than those without. No significant differences were found in IOS indices between groups based on the presence of atopic dermatitis, food sensitization, eosinophilia, inhaled corticosteroid usage or wheezing without colds. R5-R20% and total IgE values were found to be significantly related to positive mAPI (aOR: 1.40, p = 0.022 and aOR: 1.02, p = 0.001, respectively). In the ROC analysis, R5-R20% levels >14.4 had a sensitivity of 75% and specificity of 53% for predicting a positive mAPI (p = 0.003). Conclusion: IOS may help clinicians to identify the pre-school wheezers with a high risk of asthma (AU)

No disponible
Descriptores: ruidos respiratorios/fisiopatología
asma/epidemiología
-oscilometría/métodos
factores de riesgo
fenómenos fisiológicos respiratorios
valor predictivo de las pruebas
Límites: humanos
masculino
femenino
niño preescolar
Responsable: BNCS


  5 / 1401 IBECS  
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Id: 172178
Autor: Armentia, A; Martín-Armentia, S; Martín-Armentia, B; Santos-Fernández, J; Álvarez, R; Madrigal, B; Fernández-González, D; Gayoso, S; Gayoso, MJ.
Título: Is eosinophilic esophagitis an equivalent of pollen allergic asthma? Analysis of biopsies and therapy guided by component resolved diagnosis
Fuente: Allergol. immunopatol;46(2):181-189, mar.-abr. 2018. ilus, tab.
Idioma: en.
doi: 10.1016/j.aller.2017.11.001.
Resumen: Background: Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction and, histologically, by eosinophilic inflammation. There is not a clear etiologic treatment. Biopsies analysis using plant histology methods may show callose and pollen tubes in the esophageal mucosa. Component-resolved diagnosis (CRD) with microarrays could detect possible allergens involved and indicate an elimination diet and allergen immunotherapy (AIT). Methods: One hundred and twenty-nine patients with EoE were tested for environmental and food allergens. CRD, histological and botanical analysis were performed. Clinical scores and endoscopic biopsy were performed every six months for three years. Fifty healthy patients, 50 asthmatics due to pollen, and 53 celiac disease patients were included as comparison groups. CRD-directed AIT was administered in 91 EoE patients and elimination diet in 140 patients (87 EoE and all 53 CD patients). Results: CRD detected allergen hypersensitivity in 87.6% of patients with EoE. The predominant allergens were grass group 1 (55%), lipid transfer proteins (LTP) of peach and mugwort, hazelnuts and walnuts. Callose from pollen tubes was found in 65.6% of biopsies. After CRD-guided elimination diet and/or AIT, 101 (78.3%) EoE patients showed significant clinical improvement (p < 0.017) and 97 (75.2%) were discharged (negative biopsy, no symptoms, no medication) without relapse (AU)

No disponible
Descriptores: esofagitis eosinofílica/inmunología
rinitis alérgica estacional/inmunología
desensibilización inmunológica/utilización
-biopsia/utilización
tubo polínico/crecimiento & desarrollo
polen/efectos adversos
pruebas cutáneas/utilización
pruebas inmunológicas/utilización
estudios de casos y controles
fluoroinmunoanálisis/utilización
estudios longitudinales
asma/inmunología
enfermedad celíaca/inmunología
Límites: humanos
Responsable: BNCS


  6 / 1401 IBECS  
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Id: 172177
Autor: Antunes, L; Duarte de Souza, AP; Araújo, PD de; Pinto, LA; Jones, MH; Stein, RT; Pitrez, PM.
Título: iNKT cells are increased in children with severe therapy-resistant asthma
Fuente: Allergol. immunopatol;46(2):175-180, mar.-abr. 2018. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2017.05.009.
Resumen: Background: Invariant natural killer T (iNKT) cells play complex functions in the immune system, releasing both Th1 and Th2 cytokines. The role of iNKT cells in human asthma is still controversial and never described in severe therapy-resistant asthma in children. The objective of this work was to analyse iNKT frequency in peripheral blood of children with severe therapy-resistant asthma (STRA), compared to children with milder asthma and healthy controls. Methods: Children with asthma (n = 136) (non-severe and STRA) from a referral centre and healthy controls (n = 40) were recruited. Peripheral blood mononuclear cells were isolated, stained with anti-CD3 and anti-iNKT (Vα24Jα18), and analysed through flow cytometry. Atopic status was defined by measuring specific IgE in serum. Airway inflammation was assessed by induced sputum. Results: Children with asthma presented an increased frequency of CD3+iNKT+ cells (median 0.38% IQR 0.18-1.9), compared to healthy controls (median 0.26% IQR 0.10-0.43) (p = 0.025). Children with STRA also showed an increased frequency of iNKT cells (1.5% IQR 1.05-2.73) compared to healthy controls and non-severe asthmatic children (0.35% IQR 0.15-1.6; p = 0.002). The frequency of iNKT cells was not different between atopic and non-atopic children. In addition, iNKT cells were not associated with any inflammatory pattern of induced sputum studied. Conclusion: Our data suggests that iNKT cells play a role in paediatric asthma, which is also associated with the severity of disease, but independent of the atopic status (AU)

No disponible
Descriptores: asma/inmunología
antiasmáticos/uso terapéutico
células T invariantes asociadas a la mucosa/inmunología
células T asesinas naturales/inmunología
-resistencia a medicamentos/inmunología
citocinas/inmunología
células TH1/inmunología
células Th2/inmunología
antígenos CD3/inmunología
estudios transversales
Límites: humanos
masculino
femenino
niño
adolescente
Responsable: BNCS


  7 / 1401 IBECS  
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Id: 172176
Autor: Aguiar-Santos, AM; Montenegro, S; Medeiros, Z; Rocha, A; Morais, CNL; Silva, AR; Bonfim, C; Costa, TR; Sarinho, ESC.
Título: Immunomodulation of allergic response in children and adolescents: What we can learn from lymphatic filarial infection
Fuente: Allergol. immunopatol;46(2):167-174, mar.-abr. 2018. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2017.09.023.
Resumen: Background: Although it is well known that allergic diseases involve a strong Th2 immune response, with production of high levels of specific IgE allergen, knowledge on the association between filarial infection and allergies, among paediatric patients is scarce. Objective: To evaluate the allergic response patterns in cases of filarial infection by comparing peripheral eosinophils, total IgE levels, immediate hypersensitivity and cytokine levels in children and adolescents in Brazil. Methods: This was an exploratory study with three groups: (I) with filarial infection and without allergic diseases; (II) without filarial infection and with allergic diseases; and (III) without filarial infection and without allergic diseases. The prick test and specific IgE tests for aeroallergens were performed using five antigens. Peripheral eosinophils and total IgE were also evaluated. IL-4 and IL-5 were determined using whole-blood culture stimulated by three antigens. Results: Eosinophilia and elevated levels of total IgE (≥ 400IU/dl) were observed in all groups. The prick test was positive in 56.6% of the cases. Group I presented hypersensitive responses similar to the allergic disease groups. In the whole-blood culture stimulated by Dermatophagoides pteronyssinus, average IL-4 production did not differ significantly among the groups, but IL5 production resulting from stimulation was greater in the allergic disease groups (p < 0.05). Conclusions: The allergic response pattern in group with filarial infection was similar to that of the groups with and without allergic diseases, but the response to IL-5 in the culture stimulated by D. pteronyssinus was an exclusive characteristic of the allergic group (AU)

No disponible
Descriptores: filariasis linfática/inmunología
hipersensibilidad/inmunología
-filariasis linfática/complicaciones
Filarioidea/aislamiento & purificación
Dermatophagoides pteronyssinus/patogenicidad
interleucina-5/inmunología
parasitosis intestinales/epidemiología
pruebas cutáneas/utilización
eosinofilia/inmunología
Límites: humanos
niño
adolescente
Responsable: BNCS


  8 / 1401 IBECS  
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Id: 172175
Autor: Froio Toledo, M; Mangueira Saraiva-Romanholo, B; Carvalho Oliveira, R; Ferraz da Silva, L; Solé, D.
Título: Air pollution and its relationship to lung function among adolescents from Taubate, São Paulo, Brazil
Fuente: Allergol. immunopatol;46(2):160-166, mar.-abr. 2018. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2017.04.007.
Resumen: Background: This paper sought to evaluate individual exposure to air pollution by quantifying the carbon in alveolar macrophages (AMs) and its relationship to lung function. We also examined the proximity of participants' residences to the Presidente Dutra highway (PDH) in adolescents with asthma from Taubaté, São Paulo, Brazil. Methods: This descriptive study examined fifty 13- to 14-year-old adolescents with asthma identified by the International Study of Asthma and Allergies in Childhood (ISAAC) in Taubaté. These adolescents underwent spirometry and sputum induction via the inhalation of 3% hypertonic saline (HSS). Sputum was collected after each nebulisation, and forced expiratory flow in one second (FEV1) was measured. The collected sputum was stored and transported to the laboratory; it was then processed and analysed for ultrafine particles (≤100 nm). This analysis was correlated with the residence location and FEV1 of each adolescent. Results: A total of 39 adolescents completed the study. The comparison of the carbon fraction within macrophages (CA/MA) showed no differences according to residence in relation to the PDH (p=0.758). After adjustment, a mixed linear model with FEV1 as the dependent variable and CA/MA, location, and evaluation condition as the predictors found that the interactions among the variables were not significant. Conclusions:T he amount of carbon present within the AMs of adolescents with asthma was not correlated with either lung function or residence location. Evaluations of the topograghy and local climatic conditions in Taubaté should be considered in future studies (AU)

No disponible
Descriptores: contaminación del aire/análisis
materia particulada/aislamiento & purificación
asma/epidemiología
hollín/aislamiento & purificación
-contaminación del aire/efectos adversos
fenómenos fisiológicos respiratorios
hipersensibilidad respiratoria/epidemiología
hollín/efectos adversos
geografía médica
Límites: humanos
adolescente
Responsable: BNCS


  9 / 1401 IBECS  
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Id: 172174
Autor: Behniafard, N; Amirzargar, AA; Gharagozlou, M; Delavari, F; Hosseinverdi, S; Sotoudeh, S; Farhadi, E; Mahmoudi, M; Khaledi, M; Moghaddam, ZG; Aghamohammadi, A; Rezaei, N.
Título: Single nucleotide polymorphisms of the genes encoding IL-10 and TGF-Beta1 in Iranian children with atopic dermatitis
Fuente: Allergol. immunopatol;46(2):155-159, mar.-abr. 2018. tab.
Idioma: en.
doi: 10.1016/j.aller.2017.05.007.
Resumen: Background: Atopic dermatitis is an inflammatory skin disease in which both genetic and environmental factors interact to determine the susceptibility and severity of the disease. Objective: The aim of this study was to determine the association between atopic dermatitis and IL-10 and TGF-Beta1 gene polymorphisms. Methods: The allele and genotype frequencies of genes encoding for IL-10 and TGF-Beta1 were investigated in 89 patients with atopic dermatitis in comparison with 138 in the control group using the PCR-SSP method. Results: A significant increase was found in the frequency of the TGF-Beta1 codon 10/C allele among patients (p < 0.001, OR = 6.77), whereas a significant decrease was observed in the frequency of the T allele at the same position (p < 0.001, OR = 0.14). The frequency of the TGF-Beta1 codon 25/G allele in the control group was significantly higher than among patients (p < 0.001, OR = 0.08). A significant positive correlation was seen between CC (p < 0.001, OR = 15.10) and CG (p < 0.001) genotypes and AD at codons 10 and 25, respectively. The most frequent haplotypes among patients was TGF-Beta1 CG which was significantly higher than in the control subjects (50% in patients vs. 39.9% in controls, p = 0.042). A significant increase was found in the frequency of TGF-Beta CC (36% in patients vs. 7.6% in controls, p < 0.001) and TC (14% in patients vs. 0% in controls, p < 0.001) haplotypes among patients compared to controls. By contrast, the TGF-Beta1 TG haplotype was significantly lower in patients than controls (0% in patients vs. 52.5% in controls, p < 0.001). There were no significant differences in the frequency of alleles, genotypes and haplotypes of the IL-10 gene. Conclusions: We found a strong association between the polymorphisms of the TGF-Beta1 gene at codon 10 and codon 25 positions and atopic dermatitis (AU)

No disponible
Descriptores: polimorfismo de nucleótido único/inmunología
dermatitis atópica/inmunología
interleucina-10/inmunología
factor de crecimiento transformador beta1/inmunología
-dermatitis atópica/genética
predisposición genética a la enfermedad
índice de la gravedad de la enfermedad
técnicas de genotipado/utilización
haplotipos/inmunología
Irán/epidemiología
Límites: humanos
niño
Responsable: BNCS


  10 / 1401 IBECS  
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Id: 172173
Autor: Navarrete-Rodríguez, EM; Ríos-Villalobos, LA; Alcocer-Arreguín, CR; Rio-Navarro, BE Del; Rio-Chivardi, JM Del; Saucedo-Ramírez, OJ; Sienra-Monge, JJL; Frias, RV.
Título: Cross-over clinical trial for evaluating the safety of camel's milk intake in patients who are allergic to cow's milk protein
Fuente: Allergol. immunopatol;46(2):149-154, mar.-abr. 2018. tab, graf.
Idioma: en.
doi: 10.1016/j.aller.2017.06.005.
Resumen: Background: Cow's milk protein allergy (CMPA) affects between 0.6 and 0.9% of the general population, and its treatment implies the total elimination of the intake of this protein. Camel's milk has been suggested as an alternative for patients over one year of age who suffer from CMPA due to the difference in the amino acid sequence from that of cow's milk. The objective of this study was to evaluate the safety and tolerability of camel's milk in children with CMPA. Methods: Crossed clinical trial for the use of camel's milk vs. amino acid formula, carried out at the Dr. Federico Gómez Children's Hospital of Mexico (HIMFG) on patients between one and 18 years of age with diagnosed CMPA confirmed through double-blind, placebo-controlled food challenges (DBPCFCs). Only those whose allergies were confirmed were randomly placed into two groups: those to be administered camel's milk and those to be administered the amino-acid formula for two weeks, followed by a six-week wash-out period, and then a group crossing for a further two weeks. Results: 49 patients with suspected CMPA were included in the study; the diagnosis was confirmed through DBPCFCs in 15 patients, who were those who participated in the study. After having been administered camel's milk, none of the patients presented adverse effects. Conclusions and clinical relevance Camel's milk is safe and tolerable in patients above one year of age with CMPA and can be considered as a good alternative given the benefit of its taste compared to other formulas (AU)

No disponible
Descriptores: hipersensibilidad a la leche/dietoterapia
leche/utilización
-Camelus
estudios cruzados
seguridad del paciente
proteínas de la leche/efectos adversos
Límites: humanos
masculino
femenino
lactante
niño preescolar
niño
adolescente
Responsable: BNCS



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