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Búsqueda : "Allergol. immunopatol" [Revista]
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  1 / 1488 IBECS  
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Id: 180809
Autor: Chiricozzi, A; Belloni Fortina, A; Galli, E; Girolomoni, G; Neri, I; Ricci, G; Romanelli, M; Peroni, D.
Título: Current therapeutic paradigm in pediatric atopic dermatitis: Practical guidance from a national expert panel
Fuente: Allergol. immunopatol;47(2):194-206, mar.-abr. 2019. ilus.
Idioma: en.
doi: 10.1016/j.aller.2018.06.008.
Resumen: Introduction and Objectives: Atopic dermatitis (AD) is the most common cutaneous inflammatory disease in both adults and children. Although emerging therapeutic approaches are being investigated for the management of pediatric AD, it still needs to be managed with conventional treatments. This consensus document is aimed at providing an update on general management and therapies of pediatric AD, defining practical recommendations for using both topical and systemic agents. Material and Methods: A panel of experts consisting of dermatologists and pediatricians were convened in order to define statements, through a Delphi process, standardizing the management of AD in pediatric subjects in a real-world setting. Results: A set of practical recommendations obtaining an at least 75% agreement was presented. Conclusions: This set of practical recommendations represents a simple and fast snapshot on the pediatric use of common anti-AD therapeutics

No disponible
Descriptores: hormonas de la corteza suprarrenal/uso terapéutico
inhibidores de calcineurina/uso terapéutico
-consenso
testimonio experto
Límites: seres humanos
Tipo de Publicación: revisión
Responsable: BNCS


  2 / 1488 IBECS  
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Id: 180808
Autor: Bejeshk, MA; Samareh Fekri, M; Najafipour, H; Rostamzadeh, F; Jafari, E; Rajizadeh, MA; Masoumi-Ardakani, Y.
Título: Anti-inflammatory and anti-remodeling effects of myrtenol in the lungs of asthmatic rats: Histopathological and biochemical findings
Fuente: Allergol. immunopatol;47(2):185-193, mar.-abr. 2019. ilus, graf.
Idioma: en.
doi: 10.1016/j.aller.2018.09.003.
Resumen: Introduction: Asthma is a chronic inflammatory disease of the airways. In this study, we evaluated the anti-inflammatory effects of myrtenol on the inflammatory indices in the pulmonary parenchyma and airways and on the inflammatory and oxidative indices of the bronchoalveolar lavage fluid (BALF) of asthmatic rats. Methods: The allergic asthma was induced by sensitization (two weeks) followed by the inhalation of ovalbumin (four weeks). Animals were divided into two main groups: (1) Histopathology, and (2) measurement of inflammatory and oxidative biomarkers in the BALF. Each main group was subdivided into four subgroups: Control, Asthma, Asthma+Dexamethasone and Asthma + Myrtenol. (-)-Myrtenol (50 mg/kg) or Dexamethasone (2.5 mg/kg) was administered intraperitoneally once a day for one week, at the end of the inhalation period. On day 50, lung histopathologic parameters and inflammatory indices in BALF including INF-gamma, IL-10, IL-1Beta, and TNF-alfa and oxidative stress biomarkers (MDA, SOD, and GPX) were measured. Result: In the Asthma group, leukocyte infiltration, the thickness of smooth muscle and epithelium of airways wall and the number of goblet cells increased. Myrtenol reduced all of the above-mentioned indices except the epithelium thickness. It also inhibited the increase in BALF IL-1Beta, TNF-alfa and MDA and increased the levels of INF-gamma, IL-10 and SOD. Conclusion: Our results suggest that myrtenol reduced damage caused by experimental asthma by reducing the inflammatory indices, normalizing the level of interleukins and balancing oxidative stress in the lungs. It also prevented airway remodeling. Myrtenol may be suggested as a potent herbal medicine for the treatment of allergic asthma

No disponible
Descriptores: remodelación de las vías respiratorias/efectos de los fármacos
antiinflamatorios/uso terapéutico
asma/farmacoterapia
células caliciformes/patología
leucocitos/inmunología
pulmón/inmunología
mucosa respiratoria/patología
monoterpenos/uso terapéutico
-movimiento celular
células cultivadas
citocinas/metabolismo
modelos de enfermedad en animales
mediadores de la inflamación/metabolismo
ratas Wistar
mucosa respiratoria/efectos de los fármacos
Límites: seres humanos
animales
masculino
Responsable: BNCS


  3 / 1488 IBECS  
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Id: 180807
Autor: Yang, X; Wang, X; Chi, M; Zhang, M; Shan, H; Zhang, QH; Zhang, J; Shi, J; Zhang, JZ; Wu, RM; Li, YL.
Título: Osteoprotegerin mediate RANK/RANKL signaling inhibition eases asthma inflammatory reaction by affecting the survival and function of dendritic cells
Fuente: Allergol. immunopatol;47(2):179-184, mar.-abr. 2019. graf, ilus, tab.
Idioma: en.
doi: 10.1016/j.aller.2018.06.006.
Resumen: Introduction: Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Dendritic cells (DCs) are considered the most important antigen-presenting cell in asthma airway inflammatory reaction. But whether osteoprotegerin (OPG) mediate RANK/RANKL signaling inhibition influences asthma development by affecting the survival and function of DCs remains unclear. In this study, we assessed the effects of OPG on DCs and asthma. Material and methods: BALB/c mice immunized with ovalbumin (OVA) were challenged thrice with an aerosol of OVA every second day for eight days. Dexamethasone (1.0mg/kg) or OPG (50 mig/kg) was administered intraperitoneally to OVA-immunized BALB/c mice on day 24 once a day for nine days. Mice were analyzed for effects of OPG on asthma, inflammatory cell infiltration and cytokine levels in lung tissue. The expression of RANK and β-actin was detected by Western Blot. DCs were isolated from mouse bone morrow. Cell survival was assessed by cell counting. The content of IL-12 was detected by ELISA. Results: Results showed that OVA increased the number of inflammatory factors in BALF, elevated lung inflammation scores in mice. OPG reversed the alterations induced by OVA in the asthmatic mice. OPG inhibited the survival and function of DC via inhibition of RANK/RANKL signaling. Conclusions: This research proved inhibition of RANK/RANKL signaling by OPG could ease the inflammatory reaction in asthma, providing new evidence for the application of OPG on asthma

No disponible
Descriptores: asma/metabolismo
células dendríticas/fisiología
osteoprotegerina/metabolismo
neumonía/metabolismo
-presentación de antígenos
asma/inmunología
supervivencia celular
citocinas/metabolismo
ratones endogámicos BALB C
neumonía/inmunología
ligando RANK/metabolismo
activador del receptor del factor nuclear kappa B/metabolismo
Límites: seres humanos
animales
femenino
ratones
Responsable: BNCS


  4 / 1488 IBECS  
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Id: 180806
Autor: Azizi, G; Bagheri, Y; Yazdani, R; Zaki-Dizaji, M; Jamee, M; Jadidi-Niaragh, F; Kamali, AN; Abolhassani, H; Aghamohammadi, A.
Título: The profile of IL-4, IL-5, IL-10 and GATA3 in patients with LRBA deficiency and CVID with no known monogenic disease: Association with disease severity
Fuente: Allergol. immunopatol;47(2):172-178, mar.-abr. 2019. graf, tab.
Idioma: en.
doi: 10.1016/j.aller.2018.06.003.
Resumen: Background: Common variable immunodeficiency (CVID) is the most common symptomatic form of primary immunodeficiency (PID). LPS-responsive beige-like anchor protein (LRBA) deficiency is an autosomal recessive disease characterized by a CVID-like phenotype. T cell abnormality was reported in patients with CVID and LRBA deficiency. The study's aim was to evaluate IL-4, IL-5, IL-10 and GATA3 expression in patients with LRBA deficiency and CVID with no known monogenic disease, and further evaluate its relevance with immunological futures and clinical complications of patients. Methods: The study population comprised patients with CVID, LRBA deficiency and ageûsex matched healthy controls. Mutation analysis was done by whole exome sequencing in CVID patients to rule out monogenic PIDs. After CD4+ T cell stimulation with anti-CD3 and anti-CD28 monoclonal antibodies, gene expression of IL-4, IL-5, IL-10 and transcription factor GATA3 was evaluated by real-time polymerase chain reaction. The protein of mentioned cytokines was assessed by enzyme-linked immunosorbent assay. Results: The main clinical presentations of CVID patients were infections only and lymphoproliferations phenotypes, but in LRBA patients were autoimmune and enteropathy phenotype. The frequencies of CD4+ T cells were significantly reduced in LRBA and CVID patients. There were no statistically significant differences among GATA3, IL4, and IL5 gene expressions by CD4+ T cells of patients and controls, however, the IL10 expressions in CVID patients was significantly lower than in LRBA patients and HCs. As compared with HCs, CVID patients showed a prominent decrease in IL-4 and IL-10 production by CD4+ T cells. Conclusions: Our findings demonstrated that patients with CVID and LRBA deficiency (even with severe infectious and inflammatory complications) have not imbalance in Th2 response, which is in parallel with lower frequency of allergy and asthma in these patients

No disponible
Descriptores: proteínas adaptadoras transductoras de señales/genética
linfocitos T CD4-positivos/fisiología
inmunodeficiencia variable común/genética
factor de transcripción GATA3/genética
interleucina-10/genética
interleucina-4/genética
interleucina-5/genética
-autoinmunidad
análisis de mutaciones del ADN
células cultivadas
análisis de mutaciones del ADN
progresión de la enfermedad
Límites: seres humanos
masculino
femenino
niño
adolescente
adulto joven
adulto
Responsable: BNCS


  5 / 1488 IBECS  
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Id: 180805
Autor: Veenje, S; Osinga, H; Antonescu, I; Bos, B; Vries, TW de.
Título: Focus group parental opinions regarding treatment with topical corticosteroids on children with atopic dermatitis
Fuente: Allergol. immunopatol;47(2):166-171, mar.-abr. 2019. tab.
Idioma: en.
doi: 10.1016/j.aller.2018.05.007.
Resumen: Introduction and objectives:Atopic dermatitis is common among children of 0û5 years old. Treatment consists of emollients and topical corticosteroids. Due to corticophobia, however, adherence to topical corticosteroids is low. Our aim was to find factors that influence opinions about topical corticosteroids among parents of children with atopic dermatitis. Methods: A qualitative focus group study in secondary care with parents of children with atopic dermatitis. Questions concerned opinions, attitude, sources of information, and the use of topical corticosteroids. Results: The parents indicated that they lack knowledge about the working mechanism and side effects of topical corticosteroids. Dermatologists and paediatricians emphasise the beneficial effects, whereas other healthcare workers and lay people often express a negative attitude. Conclusions: This study gives a complete overview of factors influencing adherence. Treatment with topical corticosteroids can be improved by better informing parents about the working mechanisms, the use, and how to reduce the dose. Healthcare professionals need to be aware of the consequences of their negative attitude concerning topical corticosteroids

No disponible
Descriptores: hormonas de la corteza suprarrenal/uso terapéutico
dermatitis atópica/epidemiología
grupos focales
conocimientos, actitudes y prácticas sanitarias
adhesión a la medicación/estadística & datos numéricos
padres
-administración tópica
dermatitis atópica/farmacoterapia
adhesión a la medicación/psicología
Países Bajos
encuestas y cuestionarios
Límites: seres humanos
masculino
recién nacido
lactante
niño preescolar
niño
adolescente
adulto
Responsable: BNCS


  6 / 1488 IBECS  
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Id: 180804
Autor: Wahabi, Imen; Hadj Fredj, Sondess; Nefzi, Malek; Dabboubi, Rym; Siala, Hajer; Khalsi, Fatma; Bousetta, Khedija; Messaoud, Taieb.
Título: Association of M470V polymorphism of CFTR gene with variability of clinical expression of asthma: Case-report study
Fuente: Allergol. immunopatol;47(2):159-165, mar.-abr. 2019. tab.
Idioma: en.
doi: 10.1016/j.aller.2018.06.007.
Resumen: Introduction and Objectives: Asthma is a complex genetic disorder. Several genes have been found associated with asthma. The cystic fibrosis transmembrane conductance regulator (CFTR) gene is one of them. The aim of this study was to perform a comparative analysis of the genotype and allele frequency distributions of the biallelic marker M470V within the CFTR gene on mutant and wide chromosomes. Patients and methods: The molecular approach consists in the genotyping of the M470V marker by the PCR-RFLP technique in 105 asthmatic patients, aged between four months and 17 years, and 105 healthy subjects. Results: We found a significant difference in the genotype frequencies between the two studied groups (chi2 = 9.855, P = 0.007). The V/V genotype was over represented in the asthmatic group as compared to the controls (32.38% vs. 16.19%). Whereas, the M/V genotype is more frequent in healthy subjects (40.95% vs. 28.71%). We also noted a significant difference in allelic distribution of M470V with associated diseases (chi2 = 9.610, P = 0.022). Conclusions: The present study is the first report on the distribution of the M470V polymorphism in asthmatic Tunisian patients. We noticed that the M470V variant could modulate the clinical phenotype of asthmatic patients. This preliminary study will establish the molecular basis of this disease in Tunisia

No disponible
Descriptores: asma/genética
regulador de la conductancia transmembrana de la fibrosis quística/genética
genotipo
mutación/genética
-frecuencia génica
estudios de asociación genética
fenotipo
Límites: seres humanos
masculino
lactante
niño preescolar
niño
adolescente
Responsable: BNCS


  7 / 1488 IBECS  
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Id: 180803
Autor: Alyasin, S; Esmaeilzadeh, H; Ebrahimi, N; Nabavizadeh, SH; Kashef, S; Esmaeilzadeh, E; Babaei, M; Amin, R.
Título: Phenotyping and long-term follow up of patients with hyper IgE syndrome
Fuente: Allergol. immunopatol;47(2):152-158, mar.-abr. 2019. graf, tab.
Idioma: es.
doi: 10.1016/j.aller.2018.07.009.
Resumen: Introduction and objectives: Long-term follow up of patients with hyper IgE syndrome (HIES), as a primary immunodeficiency disorder, has been poorly investigated. This study describes common clinical and immunological features of patients with HIES in the last 10 years in Shiraz University of Medical Sciences, Shiraz, Iran. Methods and patients: In this cross-sectional study, the symptoms and medical records of 18 patients, who were diagnosed with HIES, were observed. Genetic and immunologic study was also performed. Results: Eighteen patients with the mean age of 13 years old were investigated. Ten patients were detected to have mutations in DOCK8 gene and autosomal recessive HIES (AR-HIES); and four patients were found with STAT3 mutation and autosomal dominant HIES (AD-HIES). So, 14 patients with known genetic results were considered for further data analysis. Food allergy, eczema, viral and skin infections were the major complications of AR-HIES patients. The major clinical complications of AD-HIES patients were pneumonia, skin infections and eczema. Food allergy and viral infection were significantly higher in DOCK8 deficient patients. The most common causes of hospitalization in both AR-HIES and AD-HIES patients were pneumonia, skin infections and sepsis. The most common cause of death was found to be sepsis. Conclusions; AD-HIES and AR-HIES cannot be differentiated only based on the clinical presentations. Genetic features are also necessary for better diagnosis. This study, summarizing the clinical, immunological and genetic information of the patients with AD-HIES and AR-HIES, may open a way for better diagnosis and management of HIES

No disponible
Descriptores: hipersensibilidad a los alimentos/inmunología
síndrome de Job/inmunología
mutación/genética
neumonía/inmunología
-estudios de seguimiento
hipersensibilidad a los alimentos/genética
predisposición genética a la enfermedad
factores de intercambio de nucleótidos de guanina/genética
síndrome de Job/genética
fenotipo
neumonía/genética
factor de transcripción STAT3/genética
Límites: seres humanos
masculino
niño preescolar
niño
adolescente
adulto joven
adulto
Responsable: BNCS


  8 / 1488 IBECS  
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Id: 180802
Autor: Navarrete-Rodríguez, EM; Rio-Navarro, BE Del; García-Fajardo, DE; Baay-Guzmán, GJ; Espinosa-Padilla, SE; Medina-Torres, EA; Moguel-Molina, NI; Sánchez-Curiel-Loyo, M; Nájera-Martínez, N; Navarro-Munguía, J; Reyes-Noriega, N; Balderrábano-Saucedo, NA; Sánchez-Urbina, R; García Delgado, C; Sienra-Monge, JJL; Morán-Barroso, VF.
Título: Microdeletion 22q11.2 syndrome: Does thymus incidental surgical resection affect its immunological profile?
Fuente: Allergol. immunopatol;47(2):141-151, mar.-abr. 2019. tab.
Idioma: en.
doi: 10.1016/j.aller.2018.06.004.
Resumen: Background: The del22q11 syndrome patients present immunological abnormalities associated to thymus alterations. Up to 75% of them present cardiopathies and thymus is frequently removed during surgery. The thymectomy per se has a deleterious effect concerning lymphocyte subpopulations, and T cell function. When compared to healthy controls, these patients have higher infections propensity of variable severity. The factors behind these variations are unknown. We compared immunological profiles of del22q11.2 Syndrome patients with and without thymectomy to establish its effect in the immune profile. Methods: Forty-six del22q11.2 syndrome patients from 1 to 16 years old, 19 of them with partial or total thymectomy were included. Heart disease type, heart surgery, infections events and thymus resection were identified. Immunoglobulin levels, flow cytometry for lymphocytes subpopulations and TREC levels were determined, and statistical analyses were performed. Results: The thymectomy group had a lower lymphocyte index, both regarding total cell count and when comparing age-adjusted Z scores. Also, CD3+, CD4+ and CD8+ lower levels were observed in this group, the lowest count in those patients who had undergone thymus resection during the first year of life. Their TREC level median was 23.6/μL vs 16.1 miL in the non-thymus group (p = 0.22). No differences were identified regarding immunoglobulin levels or infection events frequencies over the previous year. Conclusion: Patients with del22q11.2 syndrome subjected to thymus resection present lower lymphocyte and TREC indexes when compared to patients without thymectomy. This situation may be influenced by the age at the surgery and the time elapsed since the procedure

No disponible
Descriptores: linfocitos T/fisiología
subgrupos de linfocitos T/fisiología
timectomía/métodos
timo/cirugía
-cromosomas humanos par 22/inmunología
deleción cromosómica
citometría de flujo
receptores de antígenos de linfocitos T/genética
Límites: seres humanos
masculino
femenino
lactante
niño preescolar
niño
adolescente
Responsable: BNCS


  9 / 1488 IBECS  
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Id: 180801
Autor: Alves-Correia, M; Gaspar, Â; Borrego, LM; Azevedo, J; Martins, C; Morais-Almeida, M.
Título: Successful oral desensitization in children with cow's milk anaphylaxis: Clinical and laboratory evaluation up to nine-years follow-up
Fuente: Allergol. immunopatol;47(2):133-140, mar.-abr. 2019. tab.
Idioma: en.
doi: 10.1016/j.aller.2018.07.007.
Resumen: Introduction: Cow's milk protein allergy (CMPA) is the most common food allergy in children worldwide. Some children have severe and persistent CMPA, with near-fatal reactions after exposure to trace amounts of cow's milk-proteins (CMP). Strict avoidance diet is difficult, negatively affects quality of life and represents a conservative approach. Therefore, different therapeutic strategies are necessary. Objective: We aimed to assess long-term efficacy and safety of oral immunotherapy (OIT) in children with severe and long-lasting IgE-mediated CMPA. Materials and methods: The authors present four case reports of patients with CMPA who underwent CMP-OIT, that have been under long-term follow-up up to nine years. We provide information about the clinical and laboratory evaluation. Skin prick tests (SPT), specific IgE and IgG4 were performed before, during, and after OIT. Immune profile after OIT was assessed by flow cytometry (lymphocyte subsets, regulatory T and B cells). Results: The success rate was 100%, and all patients currently have a free diet with minimal diary ingestion of 200mL CMP or equivalent. Specific IgE levels and SPT to CMP have progressively decreased, and specific IgG4 levels have increased. CD4+CD25+CD127/dim regulatory T cells were increased after OIT. Conclusions: OIT ensured a clinical tolerance state after up to nine years, confirmed by both clinical and immune profile, allowing a diet without restrictions, with high satisfaction from patients and caregivers. We emphasize that OIT should be performed only by allergy experts in the hospital setting, and that only motivated families should be enrolled, since it is essential to ensure CMP daily intake at home

No disponible
Descriptores: alérgenos/uso terapéutico
desensibilización inmunológica/métodos
hipersensibilidad a la leche/terapia
linfocitos T reguladores/inmunología
-administración oral
alérgenos/inmunología
estudios de seguimiento
inmunoglobulina E/metabolismo
hipersensibilidad a la leche/inmunología
tolerancia inmunitaria
Límites: seres humanos
masculino
femenino
niño
adolescente
adulto joven
bovinos
Responsable: BNCS


  10 / 1488 IBECS  
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Id: 180800
Autor: Azevedo, J; Gaspar, Â; Mota, I; Benito-Garcia, F; Alves-Correia, M; Chambel, M; Morais-Almeida, M.
Título: Anaphylaxis to beta-lactam antibiotics at pediatric age: Six-year survey
Fuente: Allergol. immunopatol;47(2):128-132, mar.-abr. 2019. tab.
Idioma: en.
doi: 10.1016/j.aller.2018.07.008.
Resumen: Introduction: Beta-lactams are the most frequently used antibiotics in pediatric age. Anaphylactic reactions may occur and need to be properly studied, but studies in children are scarce. Objective: Characterization of case reports of anaphylaxis in children referred to an allergy department with suspected beta-lactams hypersensitivity. Materials and methods: Retrospective analysis of all children referred to our Drug Allergy Center with suspected beta-lactams hypersensitivity between January 2011 and December 2016. Description of the drug allergy work-up performed studied according to standardized diagnostic procedures of ENDA/EAACI, including specific-IgE assay, skin prick and intradermal tests and diagnostic/alternative drug challenge tests. Results: 146 children with suspected beta-lactams hypersensitivity were studied, and in 21 (14.4%) the diagnosis was confirmed. In all of them, except for three children, an alternative beta-lactam was found. In seven children (33.3% of those with confirmed beta-lactams hypersensitivity) anaphylaxis was confirmed, and all of them described reactions with cutaneous and respiratory or gastrointestinal involvement. The culprit drug was amoxicillin in six and flucloxacillin in one. In this sample, we also performed oral challenge with cefuroxime, being negative in all cases. Almost all cases of confirmed anaphylaxis (six from seven cases) were IgE mediated, with positive skin tests despite negative serum specific-IgE. Conclusions: Allergic reactions to beta-lactams, although rare in children, require a detailed clinical history and a specialized drug allergy work-up to allow a correct diagnosis as well as to avoid the possibility of a potential life-threatening reaction and provide alternative drugs

No disponible
Descriptores: alérgenos/inmunología
anafilaxia/diagnóstico
hipersensibilidad medicamentosa/diagnóstico
piel/patología
beta-lactamas/inmunología
-inmunoglobulina E/sangre
estudios retrospectivos
pruebas cutáneas
encuestas y cuestionarios
Límites: seres humanos
masculino
femenino
lactante
niño preescolar
niño
adolescente
Responsable: BNCS



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