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Id: 230506
Autor: Ye, Junbing; Deng, Kefei; Zeng, Ke; Huang, Guishu; Weng, Yusong; Yang, Kunru; Chen, Qian.
Título: Is Allium Ureteral Stent Feasible for the Treatment of Ileal-Ureteral Anastomotic Stenosis? A Case Report
Fuente: Arch. esp. urol.;77(1):113-118, 28 jan. 2024. ilus.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.15.
Resumen: Background: The conventional approach for managing ureteral stenosis involves the placement of a double-J stent. In recent years, the utilisation of Allium ureteral stent (URS) has emerged as a novel treatment alternative for ureteral stenosis. Allium URS has several advantages over traditional stents, including an extended indwelling time and reduced incidence of complications. The number of cases reported worldwide on the use of Allium URS in the treatment of ureteral stenosis is currently limited. In this paper, we present the details of a case involving the use of an Allium URS to treat ileal-ureteral anastomotic stenosis in a 67-year-old patient. We aim to assess the feasibility of using Allium URS in such cases. Case Presentation: A 67-year-old Chinese woman was referred to our hospital for the treatment of left lumbago. Urography showed left ileal-ureteral anastomotic stenosis. Computed tomography (CT) revealed severe hydronephrosis in the left kidney. Subsequently, an Allium URS was implanted via ureteroscopy. We found no instances of haematuria, lumbago or urinary tract irritation during the follow-up period. After 8 months, the patient was readmitted because of left lumbago. CT re-examination revealed that the left hydronephrosis had modestly improved. The Allium URS had detached and showed stone formation on its surface. For further treatment, ureteroscopy was performed and a new Allium URS was implanted. At 3-month follow-up, CT re-examination demonstrated that the stent had dislodged again but that the hydronephrosis in the left kidney had remarkably improved. Cystoscopy revealed that the stent had completely detached and that wall stones had attached on this surface. The stent was removed via cystoscopy. After 1 month, CT scanning showed that the left hydronephrosis of the patient had almost disappeared. Conclusion: Allium URS is effective in the treatment of hydronephrosis caused by ileal-ureteral anastomotic stenosis (AU)
Descriptores: estrechez uretral/terapia
Allium
stents liberadores de fármacos
-resultado del tratamiento
ureteroscopia
Límites: seres humanos
femenino
anciano
Tipo de Publicación: informes de casos
Responsable: ES15.1 - BNCS


  2 / 3241 IBECS  
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Id: 230505
Autor: Dong, Fuxing; Zheng, Luli; Yang, Guokai.
Título: Construction of a TF-miRNA-mRNA Regulatory Network for Diabetic Nephropathy
Fuente: Arch. esp. urol.;77(1):104-122, 28 jan. 2024. ilus, graf.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.14.
Resumen: Background: This study aims to elucidate the microRNA (miRNA)-messenger RNA (mRNA)-transcription factors (TFs) network relevant to diabetic nephropathy (DN). Methods: To investigate the molecular mechanisms underlying DN, we conducted an extensive analysis using a Gene Expression Omnibus (GEO) database, specifically GSE51784, GSE30528, GSE30529 and GSE1009. RNA samples from 66 subjects were analysed to identify differentially expressed mRNAs (DEGs) and microRNAs (DEMs) between individuals with DN and healthy controls. The data underwent preprocessing, followed by Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Gene Set Enrichment Analysis (GSEA) to unveil enriched pathways. Additionally, we constructed protein-protein interaction networks and subnetworks of modules to identify key molecular players. Results: A total of 163 DEMs and 188 DEGs were identified among the four datasets. Furthermore, we identified 37 hub genes with high connectivity and four TFs, namely E1A Binding Protein P300 (EP300), SP100 Nuclear Antigen (SP100), Nuclear Receptor Subfamily 6 Group A Member 1 (NR6A1) and Jun Dimerization Protein 2 (JDP2), which may play crucial roles in the molecular pathogenesis of DN. Additionally, we constructed a co-regulatory network involving miRNAs, mRNAs and TFs, revealing potential involvement of pathways such as the Mitogen-Activated Protein Kinase (MAPK) signalling pathway, phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signalling pathway and metabolic pathways in the pathogenesis of DN. Finally, using a docking model, we established drug-gene interactions involving key genes in the network, providing potential insights into therapeutic options. Conclusions: This study explores a gene regulation network of miRNA-mRNA-TFs, identifying potential molecular targets in the aetiology of DN. It also suggests potential targets for genetic counselling and prenatal diagnosis for DN (AU)
Descriptores: ARN mensajero/genética
ARN mensajero/metabolismo
nefropatías diabéticas/genética
nefropatías diabéticas/metabolismo
-regulación de la expresión génica
Límites: seres humanos
Responsable: ES15.1 - BNCS


  3 / 3241 IBECS  
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Id: 230504
Autor: Chang, Yanyan; Ma, Li; Dang, Xiangyu.
Título: Analysis of Sleep Quality and Its Influencing Factors in Chronic Nephritis Patients: A Survey in a Hospital
Fuente: Arch. esp. urol.;77(1):98-103, 28 jan. 2024. tab.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.13.
Resumen: Objective: The current status and influencing factors of sleep quality in chronic nephritis patients (CNPs) were explored to provide clinical basis for improving the sleep quality of these patients. Methods: A total of 197 CNPs admitted to our hospital from June 2021 to June 2023 were retrospectively analysed. The sleep status of patients was evaluated by the Pittsburgh sleep quality index (PSQI). According to the PSQI scores, patients were divided into good sleep quality (n = 93) and poor sleep quality (n = 104) groups. The clinical indicators between the two groups were detected. The influencing factors of sleep quality in CNP were explored by univariate and multivariate logistic regression analysis. Results: Statistical differences existed in age, gender, course of disease, hypertension, neutrophilic granulocyte (NEUT) percentage (NEUT %), haemoglobin (Hb), urea, total carbon dioxide (TCO2), and serum phosphorus (P) between both groups (p < 0.05). Multivariate logistic regression analysis showed that age, course of disease, hypertension, NEUT %, Hb, and TCO2 were independent influencing factors for poor sleep quality in CNPs (p < 0.05). Conclusions: Older age, longer course of disease, hypertension, higher NEUT %, lower Hb, and higher TCO2 are associated with poorer sleep quality in CNPs. Therefore, targeted interventions for sleep quality should be given priority in clinical practice (AU)
Descriptores: CALIDAD DEL SUENO
nefritis
-enfermedad crónica
Límites: seres humanos
masculino
femenino
persona de mediana edad
Responsable: ES15.1 - BNCS


  4 / 3241 IBECS  
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Id: 230503
Autor: Mi, Zezhen; Liu, Junyu; Wang, Luowu; Luo, Yuanman; Yang, Ke.
Título: Screening of Associated Factors for Erectile Dysfunction after Radical Prostatectomy and Construction of a Clinical Risk Assessment Model: A Retrospective Study
Fuente: Arch. esp. urol.;77(1):91-97, 28 jan. 2024. tab.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.12.
Resumen: Objective: In this article, the associated factors for erectile dysfunction (ED) after radical prostatectomy (RP) were explored, and a clinical risk assessment model was constructed. Methods: A total of 155 patients who underwent RP in People's Hospital of Hunan Province from November 2020, to November 2021, were selected as the study group. In accordance with the results of International Index of Erectile Function (IIEF-5) at 6 months after surgery, 88 patients were included in the ED group (IIEF-5 <22), and 67 patients were included in the non-ED group (IIEF-5 ≥22). Univariate and multivariate logistic regression analyses were conducted to screen the risk factors for ED after RP, and a risk model was constructed on this basis. In addition, 43 patients with ED after RP and 41 patients with non-ED after RP from January 2022, to January 2023, were included in the test group to evaluate the predictive efficacy of the clinical risk assessment model on the basis of the receiver operating characteristic curve. Results: The study group had a lower postoperative IIEF-5 score than before surgery (p < 0.001). The incidence of ED after RP in the study group was 56.77% (88/155). Multivariate analysis showed that advanced age (odds ratio (OR) = 1.155), large prostate volume (OR = 1.077), smoking (OR = 5.676), drinking (OR = 3.495), hypertension (OR = 8.079), diabetes (OR = 6.082), low preoperative serum testosterone (T) level (OR = 0.684) and high preoperative serum endothelin-1 (ET-1) level (OR = 1.192) were risk factors for ED after RP (p < 0.05). A risk model was constructed as follows: Z = 0.144 × (age) + 0.074 × (prostate volume) + 1.736 × (smoking) + 1.251 × (drinking) + 2.089 × (hypertension) + 1.805 × (diabetes) − 0.380 × (preoperative serum T) + 0.175 × (preoperative serum ET-1). The area under curve (AUC), sensitivity, specificity and 95% CI of this model were 0.906, 97.70%, 73.20%, and 0.848û0.964, respectively (p < 0.001)(AU)
Descriptores: neoplasias de la próstata/cirugía
prostatectomía/efectos adversos
disfunción eréctil/diagnóstico
disfunción eréctil/etiología
-estudios retrospectivos
factores de riesgo
curva ROC
Límites: seres humanos
masculino
persona de mediana edad
anciano
Responsable: ES15.1 - BNCS


  5 / 3241 IBECS  
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Id: 230502
Autor: Li, Qingchao; Su, Xiaolu; Qing, Liangliang; Xu, Wenbo; Yang, Yongjin; You, Chengyu; Wang, Jirong; Dong, Zhilong.
Título: HER2 Affects the Biological Behaviours of Bladder Cancer Cells and is Closely Associated with the Progression and Prognosis of Bladder Cancer
Fuente: Arch. esp. urol.;77(1):79-91, 28 jan. 2024. ilus, tab, graf.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.11.
Resumen: Objective: Given the growing recognition of molecular targets in oncology, this study aimed to examine the expression pattern and prognostic significance of human epidermal growth factor receptor-2 (HER2) in bladder cancer (BC) and the effects of HER2 knockdown on the biological behaviours of BC cells. Methods: A total of 126 BC tissue samples and 20 samples of normal bladder mucosa were collected for immunohistochemical staining. The clinicopathological data were obtained from patients with BC. HER2 was knocked down in two BC cell lines (T24 and 5637) using lentiviral delivery of short hairpin RNA (shRNA), referred to as shHER2, with a blank control group (shCtrl) for comparison. A range of assays, including cell counting kit-8, colony formation, transwell, wound healing, and flow cytometry, were performed to assess the effects of HER2 knockdown on the proliferation, migration, cell cycle entry, and apoptosis of BC cells. Results: The study revealed a notable overexpression rate of HER2 in BC tissues (57.1%) than in normal bladder mucosa (0%) (p < 0.001). HER2 overexpression was associated with tumour number (p < 0.0001), pathological grade (p < 0.0001), lymph node metastasis (p = 0.040), distant metastasis (p = 0.037), overall survival (p = 0.0006), and recurrence-free survival (RFS) (p < 0.0001). In contrast, no significant association was identified between HER2 overexpression and demographic factors such as sex (p = 0.687), age (p = 0.430), tumour size (p = 0.053), or T stage (p = 0.134). Furthermore, the experimental knockdown of HER2 in BC cells inhibited the proliferation and migration and promoted their apoptosis and cell cycle arrest in the G1 phase. Conclusions: The findings suggest HER2 as a potential therapeutic target for BC and underscore the promise of developing anti-HER2-targeting strategies for BC management (AU)
Descriptores: receptor ErbB-2/metabolismo
neoplasias de la vejiga/metabolismo
neoplasias de la vejiga/patología
-progresión de la enfermedad
inmunohistoquímica
pronóstico
Límites: seres humanos
Responsable: ES15.1 - BNCS


  6 / 3241 IBECS  
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Id: 230501
Autor: Liu, Xinxin; Zhao, Chunxiao; Lin, Jing; Liu, Baolong.
Título: Analysis of Factors Influencing Bone Metastasis in Prostate Cancer and Diagnostic Value of Serum PSA, CysC and D-D
Fuente: Arch. esp. urol.;77(1):72-78, 28 jan. 2024. tab, graf.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.10.
Resumen: Objective: This study aims to analyse factors influencing bone metastasis in prostate cancer and the diagnostic value of serum prostate-specific antigen (PSA), and D-dimer (D-D) combined with cystatin C (CysC) in bone metastasis of prostate cancer. Methods: Data of 116 patients with prostate cancer admitted to our hospital were retrospectively analysed. They were divided into two groups: Bone metastasis group (46 cases) and non-bone metastasis group (70 cases). Univariate and multivariate logistic regression analyses were used to determine factors influencing bone metastasis in prostate cancer. The values of serum PSA, D-D and CysC were identified using a receiver operating characteristic diagnostic curve. Results: Of the 116 patients, 46 had bone metastases and 70 had non-bone metastases. Among 46 patients with bone metastasis, 8 cases (17.39%) had single bone metastasis and 38 cases (82.61%) had multiple bone metastasis. Based on the univariate analysis, bone metastasis was associated with increases in Gleason score, clinical stage, lymph node metastasis, systemic inflammatory response index, fibrinogen to albumin ratio and alkaline phosphatase and fibrinogen levels. The Gleason score was higher than 8 points, the clinical stages ranged from T3 to T4 and the serum levels of PSA, D-D and CysC were higher in the bone metastasis group (p < 0.05). The combined value of serum PSA, D-D and CysC in the diagnosis of bone metastasis in prostate cancer was higher than the three indicators alone. Conclusions: Lymph node metastasis in T3ûT4 clinical stages with Gleason score >8 was a risk factor for bone metastasis in prostate cancer (all p < 0.05). The risk of bone metastasis in patients with prostate cancer increases with increasing Gleason clinical stage and the occurrence of lymph node metastasis. Serum PSA, D-D and CysC have certain diagnostic value in the diagnosis of bone metastasis, and their combination has the highest value (AU)
Descriptores: neoplasias de la próstata/sangre
neoplasias de la próstata/patología
neoplasias óseas/sangre
neoplasias óseas/secundario
antígeno prostático específico/sangre
-valor predictivo de las pruebas
estudios retrospectivos
Límites: seres humanos
masculino
persona de mediana edad
anciano
Responsable: ES15.1 - BNCS


  7 / 3241 IBECS  
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Id: 230500
Autor: Li, Diwen; Zhu, Yijun.
Título: Predictive Value of Systemic Immune Inflammation Index in Septic Patients with Acute Kidney Injury
Fuente: Arch. esp. urol.;77(1):67-71, 28 jan. 2024. tab.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.9.
Resumen: Background: Acute kidney injury (AKI) is common in patients with sepsis and may result in death. Systemic immune inflammation index (SII) is associated with kidney injury, but its predictive value for AKI in patients with sepsis remains unclear. Objective: This study aimed to explore the predictive value of SII in sepsis patients with AKI. Methods: From January 2020 to December 2022, 221 patients with sepsis treated in our hospital were retrospectively collected. The patients were divided into AKI group (n = 61) and control group (n = 160). Clinical characteristics and SII level were compared between the two groups, and the predictive value of SII for the occurrence of AKI was analysed. Results: The SII level (724.72 ± 235.50 vs. 522.38 ± 205.62, p < 0.001), the serum procalcitonin level (8.13 ± 15.52 vs. 4.52 ± 10.34 µg/L, p < 0.001), and the acute physiology and chronic health evaluation II score (14.26 ± 2.90 vs. 11.62 ± 2.26, p < 0.001) significantly increased in the AKI group compared with the control group, whereas the albumin level significantly decreased (30.60 ± 5.41 vs. 32.49 ± 5.31 g/L, p = 0.019). The receiver operating characteristic curve showed that SII was valuable in predicting AKI in patients with sepsis, with an area under the curve of 0.733 (95% confidence interval: 0.657û0.810, p < 0.001). The continuous renal replacement therapy intervention rate (88.52% vs. 0.00%, p < 0.001), the intervention rate of vasoactive drugs (34.43% vs. 3.75%, p < 0.001), and the hospital mortality rate (16.39% vs. 2.50%, p < 0.001) significantly increased in the AKI group compared with the control group. Conclusions: AKI was associated with poor prognosis in patients with sepsis. SII, procalcitonin and acute physiology and chronic health evaluation II (APACHE II) score were valuable in predicting the occurrence of AKI. SII may serve as a new marker in patients with sepsis (AU)
Descriptores: lesión renal aguda/sangre
lesión renal aguda/patología
inflamación
sepsis
-valor predictivo de las pruebas
estudios retrospectivos
Límites: seres humanos
masculino
femenino
adulto
persona de mediana edad
anciano
Responsable: ES15.1 - BNCS


  8 / 3241 IBECS  
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Id: 230499
Autor: Zhao, Huandong; Ding, Ruimin; Han, Jiarui.
Título: Curcumin Enhances the Anti-Cancer Efficacy of CDK4/6 Inhibitors in Prostate Cancer
Fuente: Arch. esp. urol.;77(1):57-66, 28 jan. 2024. tab, graf.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.8.
Resumen: Objective: This study aimed to investigate the potential of combining cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors with curcumin (Cur), a natural compound known for its anti-aging properties, to enhance the anti-cancer efficacy in prostate cancer (PCa). Methods: The cell viability was determined by cell counting kit-8 assay, colony forming assay and cell invasion. The cell cycle and mRNA levels of p16 (cyclin dependent kinase inhibitor 2A, CDKN2A), p21 (cyclin dependent kinase inhibitor 1A, CDKN1A) and Rb (RB transcriptional corepressor) were detected by flow cytometry and quantitative real-time polymerase chain reaction, respectively. SA-β-gal staining and interleukin 6 (IL6) mRNA levels were used to evaluate cell aging. Western blot was used to detect mechanistic targets of rapamycin (mTOR) and signal transducer and activator of transcription 3 (STAT3) pathways. Moreover, Sphere formation assay and mRNA levels of aldehyde dehydrogenase (ALDH) 1A1, CD44 and Nanog were used to determine cell stemness. Results: The combination of LY2835219 (LY, CDK4/6 inhibitor) and Cur exhibited a synergistic inhibitory effect on PCa cell proliferation (p < 0.01) and invasion (p < 0.01) and Rb gene expression (p < 0.05), as well as a synergistic promotive effect on p61 expression (p < 0.01), p21 expression (p < 0.01) and cell cycle G1 arrest in PCa cells (p < 0.05) compared with LY or Cur alone. LY and LY + Cur increased the SA-β-gal-stained cells (p < 0.01). mTOR (p < 0.01) and STAT3 pathway (p < 0.01) were decreased by LY + Cur (p < 0.01). Furthermore, LY + Cur conditioned medium (CM) inhibited cell stemness by decreasing cell spheres (p < 0.05), ALDH1A1 (p < 0.01), CD44 (p < 0.01) and Nanog (p < 0.01) compared with LY CM. Conclusions: The findings of this study suggested that the combination of CDK4/6 inhibitor and curcumin may have clinical implications for the treatment of PCa (AU)
Descriptores: curcumina/administración & dosificación
antineoplásicos/administración & dosificación
neoplasias de la próstata/farmacoterapia
cinasa 4 dependiente de la ciclina/administración & dosificación
cinasa 6 dependiente de la ciclina/administración & dosificación
-farmacoterapia combinada
resultado del tratamiento
Límites: seres humanos
masculino
Responsable: ES15.1 - BNCS


  9 / 3241 IBECS  
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Id: 230498
Autor: Liu, Meng; Ge, Xiufen; Yan, Zhen.
Título: Effect of Solution-Focused Approach on Insight and Phsychological Emotion of Patients with Nephrotic Syndrome: A Retrospective Study from the Hospital
Fuente: Arch. esp. urol.;77(1):49-56, 28 jan. 2024. tab.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.7.
Resumen: Objective: This study aims to explore the effect of the solution-focused approach on the insight and psychological emotion of patients with nephrotic syndrome (NS). Methods: The clinical data of 185 Qingdao Municipal Hospital patients with NS from December 2020 to December 2022 were selected for retrospective analysis. According to different nursing modes, the patients were divided into the control group (CG, conventional nursing, n = 90) and the study group (SG, conventional nursing + solution-focused approach, n = 95). The Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression levels of the patients, and the insight and treatment attitudes questionnaire (ITAQ) was adopted to evaluate their insight. The short form-36 health survey (SF-36) was used to evaluate the patients' quality of life. The relationship of patients' anxiety and depression levels with their insight was analysed. Results: No statistical difference in the gender, age, body mass index, education level, disease types, hypertension, hyperlipidaemia, oedema, monthly family per capita income and residence indicators of the patients in the two groups (p > 0.05) was found. The SG had distinctly lower HADS-A and HADS-D scores and a significantly higher ITAQ score than the CG after intervention (p < 0.001). After intervention, the physiological function, physiological role, vitality, social function, physical pain, general health, emotional role and mental health scores of the SG were overtly higher than those of the CG (p < 0.05). Results of the Pearson analysis show that the anxiety and depression scores are negatively correlated with the insight scores (r = û0.265, û0.255; All p < 0.001). Conclusions: The application of the solution-focused approach to NS patients can improve their insight and anxiety and depression levels with certain clinical application value, providing more directions for the follow-up treatment of NS (AU)
Descriptores: síndrome nefrótico/psicología
ansiedad/psicología
depresión/psicología
-estudios retrospectivos
Límites: seres humanos
masculino
femenino
adulto
persona de mediana edad
Responsable: ES15.1 - BNCS


  10 / 3241 IBECS  
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Id: 230497
Autor: Bogdan Borz, Mihnea; Horia Schitcu, Vlad; Crisan, Nicolae; Petrut, Bogdan; Buhas, Bogdan Adrian; Borz, Paul Cristian; Valean, Dan; Duquesne, Igor; Coman, Ioan.
Título: Post-Pandemic Aftermath: A Two-Year Follow-Up of the Effect of COVID-19 on Oncological Outcomes after Radical Prostatectomy for Prostate Cancer
Fuente: Arch. esp. urol.;77(1):43-48, 28 jan. 2024. tab.
Idioma: en.
doi: 10.56434/j.arch.esp.urol.20247701.6.
Resumen: Purpose: This study aimed to evaluate the indirect effect of the Coronavirus Disease 2019 (COVID-19) pandemic on the surgical outcomes and oncological results of patients who underwent surgery during the lockdown period. Methods: We analysed data from 423 patients who underwent radical prostatectomy between 2016 and 2022, with a cut-off date of March 16, 2020. Patients were categorised into two groups, namely, pre-lockdown (n = 289) and during lockdown (n = 134). Perioperative variables, histopathological findings and oncological outcomes, including prostate-specific antigen (PSA) levels and biochemical recurrence (BCR), were assessed. Results: The number of radical prostatectomy increased by 24.26% during lockdown. The study included patients with a mean follow-up of 21 months. A nonsignificant trend towards a higher PSA level at presentation was found (14.22 vs. 12.53 ng/dL, p = 0.216). The International Society of Urological Pathology grade was not significantly different among radical prostatectomy specimens (p = 0.669). Lymph node involvement increased during the COVID-19 period (p = 0.046). The pT classification in prostatectomy specimens increased during the pandemic, but the difference from the pre-pandemic value was not statistically significant. The BCR rates were 24.6% pre-lockdown and 29.9% during lockdown (p = 0.136). Conclusions: The COVID-19 pandemic led to poor postoperative results. Through a 2-year follow-up, this research investigated the effect of the pandemic on the oncological outcomes, particularly BCR, of patients who underwent radical prostatectomy. Further extended investigations and multi-institutional studies should be conducted to quantify the effect of the pandemic on various cancer outcomes and inform crisis management strategies (AU)
Descriptores: /epidemiología
COVID-19/epidemiología
neoplasias de la próstata/cirugía
-resultado del tratamiento
estudios de seguimiento
prostatectomía
Límites: seres humanos
masculino
Responsable: ES15.1 - BNCS



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