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Id:	229991
Autor:	Fitria, Najmiatul; Husnia, Khairatul; Tri Ananta, Fahira; Oktavia Sari, Yelly.
Título:	The effect of pillbox use in increasing patients' adherence to type 2 diabetes mellitus therapy in Lubuk Kilangan health center
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. tab.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2904.
Resumen:	Adherence is the extent to which the patient takes the medication as determined by the health care provider. The success of a patient's therapy is strongly influenced by adherence to the use of the drug. Low adherence to therapy is a particular problem in patients with diabetes mellitus. Diabetes mellitus is a chronic metabolic disease characterized by elevated blood glucose levels, which cause damage to the heart over time, vasculature, eyes, kidneys, and nerves. The pill count method was used by calculating the rest of the drug from the patient to assess the patient's level of adherence. Objective: Adherence assessments are carried out through the Home Medication Review program. This study aimed to determine the differences in therapy adherence of patients with type 2 diabetes mellitus using the pill count method. Method: This type of research is experimental with pretest-posttest control group design research. This method is selected because the calculation of the rest of the drug is carried out before and after the intervention is given. Sampling in this study uses the total sampling method. The data was taken from Chronic Disease Management Program patients with type 2 diabetes mellitus treated at the Lubuk Kilangan Padang Health Center for January-March 2022. There are two groups of patients: patients with and without pillboxes. The data analysis used in this study is the Mann-Whitney Test. Result: The results showed a difference in the level of therapeutic adherence between the pillbox group and those who did not use the pillbox, with a value of p = 0.000 (p<0.05). Conclusion:It can be concluded that the level of adherence is higher in patients who use pillboxes than in those who do not (AU)
Descriptores:	diabetes mellitus tipo II/farmacoterapia adhesión a la medicación hipoglicemiantes/uso terapéutico
	-factores socioeconómicos Indonesia
Límites:	seres humanos masculino femenino adulto anciano
Responsable:	ES15.1 - BNCS

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Id:	229990
Autor:	Abutaima, Rana; Abufarha, Rana; Thiab, Samar; Alhamad, Hamza; Albahar, Fares.
Título:	Cross-Sectional Assessment of Pharmacy Students' Knowledge and Perception of Drug-Drug Interactions with Over the Counter Products
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. tab, graf.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2901.
Resumen:	Background: Self-medication with over-the-counter products has dramatically increased following coronavirus disease of 2019 pandemic. For safe public use of these products, Pharmacy and Doctor of Pharmacy students are expected to have proper knowledge and perception towards these products dispensing and associated interactions. Objectives: A cross-sectional survey was developed to assess Pharmacy and Doctor of Pharmacy students' knowledge and perception towards drug interactions of over the counter products. Methods: Data were collected using a self-administered questionnaire and statistically analyzed. Descriptive statistics (frequency) were analyzed for participants' demographics. Multivariable logistic regression analysis was used to determine the association between over the counter products and relevant interactions with medications to treat chronic illnesses. A P value < 0.05 was used to determine statistical significance. Results: Responses were 411 and only 389 were included. 76.6% were studying Bachelor of Pharmacy and 86.1% were on a regular study program. Recipients of Pharmacy training were 65.3% and 62.0% of participants studied over the counter course. Orphenadrine muscle relaxant was the mostly identified over the counter product (n= 339, 87.1%). Majority of students (n= 345, 88.7%) consider that OTC products help improving conditions being dispensed for. Bridging students and those who studied over the counter course showed significant knowledge in drug interactions compared to regular-program students and those who did not complete the course (P= 0.004, P< 0.001, respectively). Of the 389 respondents, 79.9% and 79.2% considered hydrochlorothiazide and metformin as over the counter products, respectively, compared to 54.0% for amoxicillin (AU)
Descriptores:	conocimientos, actitudes y prácticas sanitarias interacciones farmacológicas estudiantes de farmacia
	-encuestas y cuestionarios
Límites:	seres humanos masculino femenino adulto joven
Responsable:	ES15.1 - BNCS

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Id:	229989
Autor:	Wang, Qinbo; Zhou, Yuan; Ye, Guozeng; Ou, Yingjuan; Huang, Lihong; Liu, Wenfeng; Li, Xiaoyan; Wu, Xia.
Título:	Effect of medication therapy management on discharged patient with Ulcerative Colitis with initial stage biotherapy: a randomized study
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. tab, graf.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2894.
Resumen:	Purpose: The aim of this study was to explore the effects of medication therapy management in improving perception, medication adherence, and disease control in UC patients with first-stage of biotherapy. Subjects and Methods: A total of 120 patients with UC who received first-stage biotherapy participated in this study. The patients were divided into MTM group and CFU group. Both groups received three times follow-up, which were carried out at first, third, and sixth discharged month, Group A was followed with the MTM method, and Group B received conventional follow-up. MDRKT was used to assess patient perception, adherence to treatment was assessed by MMSA-8, and we also explored disease control and patient satisfaction. Results: A total of 116 patients completed the survey, the MTM group showed a significant improvement in perception, 84.2% of patients can correctly handle ADEs and 82.5% of patients knew what to do when they leak medication, 87.8% of patients in the MTM group had better adherence than 71.2% in the CPU group (P<0.05). The evaluation of disease control showed that 56.1% of patients in the Group A were in remission which was significantly higher than 32.2% in the Group B (P<0.05). Furthermore, the result of the questionnaire survey showed that perception, ADE, self-management, anxiety, and satisfaction were better in the MTM group than in the CPU group (P<0.05). Conclusion: The MTM group was effective in improving medication adherence, perception, and satisfaction in the patient with ulcerative colitis treated with first-stage biotherapy, and the disease control significantly improved (AU)
Descriptores:	colitis ulcerosa/farmacoterapia adhesión a la medicación terapia biológica
	-resultado del tratamiento
Límites:	seres humanos masculino femenino adolescente adulto joven adulto persona de mediana edad anciano ancianos de 80 o más años
Tipo de Publicación:	ensayo clínico controlado aleatorizado
Responsable:	ES15.1 - BNCS

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Id:	229988
Autor:	Waddah Alwadi, Maysaa; Badaineh, Rawan; Alwedyan, Tareq; Gogazeh, Esraa; A. Badir, Ola.
Título:	Assessment of the knowledge and practice of Jordanian family medicine practitioners regarding vitamin B12 screening for type 2 diabetes mellitus patients on metformin
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. tab, graf.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2893.
Resumen:	Background: Metformin is one of the most important treatments for type 2 diabetes mellitus (T2DM) patients. Mostly metformin has a safe profile but in some cases, it may cause some serious long-term hematological and neurological side effects mainly due to vitamin B12 deficiency. It is proven that there is a strong association between B12 deficiency and hematological and neurological manifestations, especially for T2DM patients on metformin. Hence, the American Diabetic Association (ADA) recommends vitamin B12 screening for those on metformin for a long duration. Objectives: To evaluate the knowledge and practice of family physicians among diabetic patients on metformin, and to evaluate the factors that enhance and prevent vitamin B12 screening. Method: A validated questionnaire was designed and distributed online for family medicine practitioners between the period of in June and September 2022. 147 family physicians participated in the study. A scoring system was used to calculate the knowledge, practice, and total scores. Results: The results reveal a high total knowledge score among participants about vitamin B12 manifestations and screening in T2DM patients. However, only half of the participants follow the ADA recommendations routinely (53.06)%. The total practice score is low as most participants (87.7%) answer only 9 of 18 questions correctly. Moreover, the results show that those who follow ADA recommendations routinely have better knowledge and practice scores (p-value 0.00406). Conclusion: More awareness about ADA recommendations and the practice of vitamin B12 screening in T2DM patients who use metformin for family physicians is required, either by encouraging them to order B12 through workshops and continuous learning programs or by the availability of tools needed to test B12 (AU)
Descriptores:	conocimientos, actitudes y prácticas sanitarias diabetes mellitus tipo II/farmacoterapia metformina/uso terapéutico hipoglicemiantes/uso terapéutico deficiencia de vitamina B12
	-encuestas y cuestionarios
Límites:	seres humanos masculino femenino adulto persona de mediana edad
Responsable:	ES15.1 - BNCS

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Id:	229987
Autor:	Supapaan, Teeraporn; Jamlongpeng, Chinnawat; Yangyuen, Natthapon; Srisawai, Komkrit; Prachuabaree, Lersak; Wattanawong, Wannaporn; Anansushatgul, Jirana; Songmuang, Thanatcha; Sripa, Saksit; Pitchayajittipong, Chonladda.
Título:	Enhancing extemporaneous preparations in Thai Hospitals: exploring variation, common formulations, and challenges and needs related to extemporaneous preparations
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. tab.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2892.
Resumen:	Objective: This study aimed to assess the diversity of extemporaneous preparations, identify the prevalent formulations, and highlight the challenges and opportunities for standardization and improvement of extemporaneous preparation practices. Methods: A survey was conducted among 88 Thai hospitals representing the public and private sectors. The questionnaire gathered information on general hospital characteristics, detailed aspects of extemporaneous compounding, and the specific extemporaneous formulations used. Results: The survey revealed significant variations in extemporaneous preparations among Thai hospitals, with oral liquids, semisolids, and eye preparations commonly employed. The primary oral liquid formulations used were suspensions, syrups, and solutions. Specific medications frequently used in extemporaneous preparations were also identified. The challenges encompassed space, personnel, skills, raw materials, equipment, standardized formula information, preparation process information, funding, and other factors. Conclusion: A survey among Thai hospitals revealed significant variations in extemporaneous preparations in 88 participating hospitals. Common formulations used in extemporaneous compounding include oral liquid preparations, such as suspensions, syrups, solutions, semisolid preparations, and eye preparations. Stakeholder involvement, implementation of standardized operating procedures, resource allocation, comprehensive training programs, and collaboration among hospitals, pharmaceutical companies, and regulatory agencies are recommended to enhance extemporaneous compounding practices (AU)
Descriptores:	servicio hospitalario de farmacia composición de medicamentos preparados farmacéuticos
	-encuestas y cuestionarios Tailandia
Límites:	seres humanos
Responsable:	ES15.1 - BNCS

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Id:	229986
Autor:	Salem Al-Dossari, Dalal; Ali Laghbi, Yahya; Saud Almutairi, Abdullah; Mohammad Alsupail, Meshal; Khulaif Alharbi, Fuad; Hamdan Alharbi, Mohammed; Alotaibi, Saud; Farooq, Anam; Ali, Sheraz.
Título:	Impact of telepharmacy on patients' outcome during COVID-19: a systematic literature review
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. tab, ilus.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2883.
Resumen:	Background: Coronavirus disease (COVID-19) continues to be a major global public health issue. COVID-19 is highly contagious, and numerous mitigation strategies have recently been implemented to prevent the spread of this disease. Pharmacists utilize telecommunication technology to provide patient care services, thus increasing patient access to pharmaceutical services. There was a scarcity of evidence regarding the impact of telepharmacy on patient outcomes during COVID-19. Therefore, the aim of this study was to summarize the available research evidence on the impact of telepharmacy on patient outcomes during COVID-19. Methods: A systematic literature search was conducted between January 2020 to September 2022 in Ovid MEDLINE, Ovid Embase, and Cochrane Central Register of Controlled Trials, using appropriate terms on telepharmacy, COVID-19, and patient outcomes. Only studies that investigated the impact of telepharmacy on patient outcomes during COVID-19 were included. A systematic literature search was conducted between January 2020 to September 2022 in Ovid MEDLINE, Ovid Embase, and Cochrane Central Register of Controlled Trials, using appropriate terms on telepharmacy, COVID-19, and patient outcomes. Only studies that investigated the impact of telepharmacy on patient outcomes during COVID-19 were included. Results: A total of three studies were included in the review. The telepharmacy services were offered via virtual anticoagulation clinic, retail community telepharmacy through information technology tools, and RxLive® telepharmacy program. All studies included in the review demonstrated that the provision of telepharmacy services during COVID-19 had an overall positive impact on the patient outcomes such as a reduction in the rates of hospitalisation and medication-related problems and maintaining the international normalized ratio values within the therapeutic range (AU)
Descriptores:	/epidemiología COVID-19/epidemiología servicios farmacéuticos comercio electrónico
	-/epidemiología ARABIA SAUDI/epidemiología
Límites:	seres humanos
Tipo de Publicación:	revisión sistemática
Responsable:	ES15.1 - BNCS

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Id:	229985
Autor:	A. Wali, Haytham; Alshehab, Nura; Al-Omran, Zainab; Al-Maghem, Sara; Al-Dughaim, Noura; Al-Shamrani, Jawaher; Y. Alshami, Mohammed; M. Kurdi, Sawsan; S. Almulhim, Abdulaziz.
Título:	Efficacy and Safety of Weight-based Dosing of Daptomycin in Obese Patients: A Systematic Review
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. tab.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2882.
Resumen:	Purpose: To provide a comprehensive review of daptomycin weight-based dosing methods for obese patients. Methods: PubMed, Embase, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched through December 31, 2022. Studies relevant to daptomycin weight-based dosing methods in obese adult patients were included. Results: Sixteen studies were included, of which five were case reports and 11 were cohort studies. Obese patients were included in all case reports, of which one was pregnant. The infections improved after receiving a daptomycin dose based on actual body weight (ABW) in all cases. Seven studies demonstrated that ABW, ideal body weight (IBW), and adjusted body weight (AjBW)-based daptomycin dosing differed in terms of treatment success, microbiological clearance, and creatinine phosphokinase (CPK) elevation. However, AjBW was not statistically equivalent to ABW in all evaluated outcomes, except for treatment success. Three studies showed a higher area under the concentration-time curve (AUC) by 60% in obese patients, whereas two studies indicated a higher maximum plasma concentration (Cmax) of ~2 folds. One study demonstrated that obese patients had higher levels of total clearance and volume of distribution, whereas other pharmacokinetic parameters were comparable between obese and non-obese patients. Conclusion: While most of the available evidence reported daptomycin dosing based on actual or total body weight, a few other studies have reported the use of ideal or adjusted body weight. A significant elevation in CPK was observed when daptomycin was administered based on AdjBW, but not with ABW and IBW. Further research is required to determine the optimal daptomycin weight-based dosing method in obese patients (AU)
Descriptores:	seguridad del paciente dosificación daptomicina/administración & dosificación antibacterianos/administración & dosificación obesidad
Límites:	seres humanos
Tipo de Publicación:	revisión sistemática
Responsable:	ES15.1 - BNCS

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Id:	229984
Autor:	Oliveira, Camila Martins; Sena, Maria Pantoja Moreira de; Sales, Clarisse Andrade; Capim, Leiliane de Paula dos Santos; Mello, Amanda Gabryelle Nunes Cardoso; Vieira, Jose Luiz Fernandes; Ribeiro, Carolina Heitmann Mares Azevedo; Sena, Luann Wendel Pereira de.
Título:	Spatial analysis of a case of reverse logistics of medicines in community pharmacies in Brazil - a preliminary study
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. tab, mapas.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2878.
Resumen:	Background: The reverse logistics of medicines consists of the logistical procedure of collection, transport, storage, treatment and final disposal of post-consumer or expired waste. Medicines can be toxic to the environment and affect the health of citizens of the territory. Community pharmacies, as a health facility, play a key role in this process. Objectives: Define the spatial analysis and cases of reverse logistics of medicines in community pharmacies in Brazil. Methods: This is a cross-sectional study, and the research covered the medicines collected by 400 community pharmacies in the period from 2020 to 2022. To obtain the data, the medicines were collected, weighed, segregated and the weight released on a dedicated waste management platform. All regions of Brazil subject to georeferencing were processed using the free software Geographic Information System (QGIS). Data were expressed as median and range or as frequency of occurrence. Chi-square t-test and Fisher's exact test were used to compare variables. The accepted significance level was 5%. Results: Of the five existing regions in Brazil, only three had records of reverse medication logistics. 4,519.74 Kg of products were collected, and the North region of Brazil was responsible for 69.1% of the collection. In the spatial analysis, it was possible to perceive a difference between the areas of concentration of the RDL, that is, locations where collections were carried out in the period from 2020 to 2022. Conclusion: The present study preliminarily analyzed the reverse logistics of medicines in Brazil. The data obtained can contribute to the knowledge of this area and to the strengthening of the process. Thus, these places must exercise a task force for the educational process of the population about the risks of incorrect disposal of medicines and that this could harm the environment, economic aspects of society, food and the entire context that involves health and well-being. of citizens (AU)
Descriptores:	servicios de farmacia comunitarios logística reversa análisis espacial
	-estudios transversales estudios retrospectivos
Límites:	seres humanos
Responsable:	ES15.1 - BNCS

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Id:	229983
Autor:	Hernández-Vásquez, Akram; Visconti-Lopez, Fabriccio J; Solorzano-Salazar, Dustin M; Barrenechea-Pulache, Antonio.
Título:	Prevalence and factors associated with self-medication for COVID-19 prevention using disproven drugs in Peru: a cross-sectional nationwide study
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. ilus, tab.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2877.
Resumen:	Objective: The objective of this study was to identify the prevalence and factors associated with the use of drugs without evidence for the prevention of COVID-19 in Peruvians without symptoms or diagnosis, using the National Household Survey (ENAHO) 2021. Methods: A secondary analysis was made of the ENAHO 2021. We evaluated participants older than 18 years who did not undergo any test to diagnose COVID-19 and used any drug to prevent COVID-19. Adjusted prevalence ratios (aPRs) were estimated to determine the associated factors. Results: Among the 69,815 participants analyzed, the prevalence of taking a drug 4 weeks prior to the survey was 5.64%. Factors associated with drug consumption were: age 30-59 years (aPR 1.47; 95% confidence interval [CI]: 1.32-1.65); having a higher education (aPR 1.73; 95% CI:1.28-2.33); having a chronic disease (aPR 1.40; 95% CI: 1.26-1.56); not having poverty status (aPR 1.40; 95% CI: 1.26-1.56); living in an urban area (aPR 1.61; 95% CI: 1.31-1.99). Meanwhile, living in the highlands (aPR 0.77; 95% CI: 0.60-0.97) and not having a landline, cell phone, television or internet at home (aPR 0.65; 95% CI: 0.43-0.98) were protective factors from unnecessary drug consumption. Conclusion: It is concerning that even after one year of living with the pandemic and having refuted the utility of medications such as ivermectin and azithromycin, these drugs are still widely consumed by a sector of the population without symptoms or a diagnosis of COVID-19. Therefore, it is necessary to formulate and implement public health measures that address this problem, taking into account the associated factors to reduce this consumption (AU)
Descriptores:	automedicación/estadística & datos numéricos /prevención & control COVID-19/prevención & control
	-estudios transversales prevalencia Perú/epidemiología
Límites:	seres humanos masculino femenino adulto persona de mediana edad
Responsable:	ES15.1 - BNCS

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Id:	229982
Autor:	Mosiane, Thokozile; Mabope, Lindi; Mncwangi, Nontobeko.
Título:	A review of the career choices of Sefako Makgatho Health Sciences University pharmacy graduates from 2015 to 2019 û A pilot study
Fuente:	Pharm. pract. (Granada, Internet);21(4), oct.- dec. 2023. graf.
Idioma:	en.
doi:	10.18549/PharmPract.2023.4.2876.
Resumen:	Introduction: The pharmacy profession is dynamic; continually expanding in new directions, offering interdisciplinary professional education and work- based learning opportunities. Many factors influence individual choices to study pharmacy and progression within the various sectors of pharmacy. Objectives: To review the career paths of Sefako Makgatho Health Sciences pharmacy graduates from the year 2015 to 2019, internship and community service placements and to explore current employment status. Methods: A descriptive and quantitative study design was followed using an online questionnaire that was originally developed using Google Forms®. The study sample included pharmacy graduates from 2015 to 2019. Researchers captured data from the questionnaires on Microsoft Office ExcelÖ (2016) spreadsheets. Key findings: The majority (78.1%) of the graduates are employed full time with only 5% unemployed. Most of the graduates felt well prepared for hospital pharmacy (64.2%) by the BPharm programmed offered at SMU with only a few graduates (5.3%) who felt that they were prepared for industrial pharmacy. It was also noted that 70.3% of the graduates are still at the operational level and only 4.4% are in executive positions. Recommendations and Conclusions: The response rate can be improved by allowing more time for graduates to respond. Graduates are advised to update their contact details on the SAPC register to facilitate communication with them. The pilot study demonstrated that the SMU School of Pharmacy had several graduates who are employed in the public sector as they felt best prepared for hospital pharmacy practice compared to any other sector (AU)
Descriptores:	estudiantes de farmacia/estadística & datos numéricos elección de carrera
	-encuestas y cuestionarios proyectos piloto
Límites:	seres humanos
Responsable:	ES15.1 - BNCS

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