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Búsqueda : "Allergol. immunopatol" [Revista]
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  1 / 2067 IBECS  
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Id: 231093
Autor: Cronin, Caoimhe; Salzberga, Noah; Woon, Yuxin; Trujillo Wurttele, Juan.
Título: Primary, secondary and tertiary prevention of food allergy: current practices and future directions / Prevención primaria, secundaria y terciaria de la alergia alimentaria: prácticas actuales y direcciones futuras
Fuente: Allergol. immunopatol;52(2):32-44, mar. 2024. ilus.
Idioma: en.
doi: 10.15586/aei.v52i2.1023.
Resumen: The incidence of food allergies has risen around the globe, and experts have been exploring methods of preventing such allergies in young children to ease the burden of disease and reduce the morbidity and mortality caused by anaphylaxis to food allergens. Such preventative measures can be categorised as primary, secondary and tertiary prevention, which are discussed in detail in this review. Primary prevention is defined as the prevention of becoming sensitised towards specific allergens. The evidence suggests that avoiding common allergenic foods during pregnancy and breastfeeding is not protective against food allergies, and guidelines recommend weaning from 4 to 6 months of age, with recent studies supporting the early introduction of peanuts at 4 months to prevent peanut allergy. Secondary prevention targets patients who are already sensitised and aims to halt the progression of sensitisation, with evidence for high rates of success and safety in trials of early introduction to milk and peanuts using oral immunotherapy in sensitised infants. Tertiary allergy prevention focuses on reducing the risk of a patient having anaphylaxis, with oral immunotherapy being the most common method of promoting tolerance in allergic children. Several studies have demonstrated successful reintroduction for milk, egg and peanut; however, no such guidelines are recommended for other foods. Finally, dietary advancement therapy in the form of milk and egg ladders has been employed as a method of primary, secondary and tertiary prevention of allergies, particularly in Ireland, the UK and Canada.(AU)
Descriptores: hipersensibilidad a los alimentos
prevención primaria
prevención secundaria
prevención terciaria
incidencia
anafilaxia/mortalidad
-alergia e inmunología
hipersensibilidad
pediatría
prevención de enfermedades
anafilaxia/prevención & control
Límites: seres humanos
masculino
femenino
niño
adolescente
Tipo de Publicación: revisión
Responsable: ES15.1 - BNCS


  2 / 2067 IBECS  
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Id: 231092
Autor: Villalobos Violán, Victoria; González Cano, Beatriz; Racionero Casero, Miguel Ángel; González-Mancebo, Eloína; Mohedano Vicente, Esther; Trujillo Trujillo, María Jesús; Gandolfo-Cano, Mar.
Título: Real-life experience after 3 months with tezepelumab before marketing approval / Experiencia de la vida real después de 3 meses con tezepelumab antes de la aprobación de comercialización
Fuente: Allergol. immunopatol;52(2):80-82, mar. 2024. tab.
Idioma: en.
doi: 10.15586/aei.v52i2.1063.
Resumen: Background: Tezepelumab is a monoclonal antibody targeting thymic stromal lymphopoietin (TSLP), implicated in asthma pathogenesis, and that has been approved for patients with severe uncontrolled asthma in Spain in October 2023. This study evaluates our experience with Tezepelumab for those patients who received the indicated drug off-label prior to its commercialization. Methods: We conducted a real-life observational study on three patients from the Severe Asthma Unit of the Hospital Universitario de Fuenlabrada, Spain, who received Tezepelumab off-label before its official approval. We analyzed symptoms control based on ACT, exacerbations, reductions in the doses of oral corticosteroid, lung function, blood changes and safety at 3 months of treatment. Results: Tezepelumab demonstrated efficacy in improving asthma control and a notable reduction in emergency department visits. OCS use decreased, with one patient halving their prednisone dose. Lung function, particularly FEV1 and FEV1/FVC parameters, improved, but no significant changes were observed in FeNO levels, blood eosinophil counts and total IgE. The treatment exhibited a favorable safety profile with no reported adverse effects during the study period. Conclusions: In this preliminary real-world experience prior to the official approval of tezepelumab in Spain, this monoclonal antibody showed promising results and suggests its potential as a valuable alternative for the treatment of severe asthma.(AU)
Descriptores: asma/complicaciones
asma/farmacoterapia
productos biológicos/administración & dosificación
anticuerpos monoclonales
LINFOPOYETINA ESTROMAL TIMICA
-España
asma/diagnóstico
hipersensibilidad respiratoria
alergia e inmunología
Límites: seres humanos
masculino
femenino
Tipo de Publicación: estudio observacional
Responsable: ES15.1 - BNCS


  3 / 2067 IBECS  
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Id: 231091
Autor: Carreras Kàtcheff, Sofia; Labrador-Horrillo, Moises; Bartolomé, Borja; Garriga-Baraut, Teresa.
Título: Allergy to Gibberellin-regulated proteins in an adolescent: A case of orange-induced anaphylaxis mediated by cofactors / Alergia a proteínas reguladas por giberelinas en un adolescente: un caso de anafilaxia inducida por naranja mediada por cofactores
Fuente: Allergol. immunopatol;52(2):48-50, mar. 2024. ilus, tab, graf.
Idioma: en.
doi: 10.15586/aei.v52i2.1014.
Resumen: This report is a case of anaphylaxis in an adolescent due to allergy to gibberellin-regulated proteins mediated by cofactors, in probable relation to a pollen/food allergy syndrome. It should also emphasizes the importance of obtaining a faithful clinical history, especially when it comes to adolescent patients as they tend to initiate toxic habits.(AU)
Descriptores: hipersensibilidad a los alimentos
anafilaxia/farmacoterapia
giberelinas
Citrus sinensis/toxicidad
conjuntivitis bacteriana
rinitis alérgica estacional
-pacientes ingresados
exploración física
hipersensibilidad
alergia e inmunología
Límites: seres humanos
masculino
adolescente
Tipo de Publicación: informes de casos
Responsable: ES15.1 - BNCS


  4 / 2067 IBECS  
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Id: 231090
Autor: Alrafiaah, Abdulaziz S; Netchiporouk, Elena; Ben Shoshan, Moshe.
Título: Cold-induced anaphylaxis triggered by drinking cold water
Fuente: Allergol. immunopatol;52(2):45-47, mar. 2024. ilus.
Idioma: en.
doi: 10.15586/aei.v52i2.1041.
Resumen: Cold urticaria is an inducible urticaria in which hives and angioedema appear after exposure to cold. The symptoms of cold urticaria often are limited to hives/angioedema. However, in up to 20% of cases, cold exposure may trigger anaphylaxis. We report the case of an 11-year-old boy previously diagnosed with chronic spontaneous urticaria who developed facial swelling, itchy hives, difficulty in breathing, vomiting and abdominal pain within 5 minutes of drinking cold water. He received a standard dose of non-sedating second-generation antihistamines at home. He was observed in the emergency room for 2 hours and discharged with an epinephrin autoinjector. During the subsequent outpatient clinic visit, an ice cube test was performed which confirmed the new diagnosis of comorbid cold-induced chronic urticaria. On further questioning, the parents reported occurrence of hives following swimming in the swimming pool. Cold-induced urticaria should be suspected in cases of anaphylaxis associated with cold exposure. Patients with chronic forms of urticaria who present with new anaphylaxis should be assessed for a potential concomitant cold-induced form. (AU)
Descriptores: urticaria
URTICARIA CRONICA
anafilaxia
respuesta al choque por frío
angioedema
vómitos
dolor abdominal
Límites: seres humanos
masculino
niño
Tipo de Publicación: informes de casos
Responsable: ES15.1 - BNCS


  5 / 2067 IBECS  
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Id: 231089
Autor: Mazurek Durlak, Zofia; Mularczyk, Katarzyna; Kwinta, Przemko; Lis, Grzegorz; Cichocka Jarosz, Ewa.
Título: Omalizumab in the treatment of Morbihan syndrome in an adolescent girl û case report and literature review
Fuente: Allergol. immunopatol;52(2):32-44, mar. 2024. ilus, tab.
Idioma: en.
doi: 10.15586/aei.v52i2.978.
Resumen: Morbihan syndrome (MS) is characterized by solid facial edema, usually related to rosacea or acne vulgaris. The facial edema deforms the patient's features, can impair peripheral vision, and affects quality of life. Its pathophysiology remains unclear. The disease usually has a slow and chronic course. MS most commonly affects middle-aged Caucasian men with rosacea and is rare in people below 20 years of age. MS is a diagnosis of exclusion. There is no standard treatment for MS, though systemic isotretinoin and antihistamines are mainly used. We present the case of an adolescent girl with MS nonresponding to 19 months of isotretinoin treatment with add-on antihistamines. Therapy with monthly administration of omalizumab (anti-IgE) for 6 months was an effective therapeutic option, improving the quality of life. Our case is the second description of omalizumab use in Morbihan syndrome, the first in an adolescent. (AU)
Descriptores: edema
rosácea
acné vulgar
isotretinoína
antagonistas de los receptores histamínicos
omalizumab
Límites: seres humanos
adolescente
adulto joven
Tipo de Publicación: informes de casos
Responsable: ES15.1 - BNCS


  6 / 2067 IBECS  
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Id: 231088
Autor: Azzi, Vanessa; Maria Karam, Joya; D'Andrea, Wendy; Malaeb, Diana; El Khatib, Sami; Sakr, Fouad; Dabbous, Mariam; Hallit, Souheil; Soufia, Michel.
Título: Are the presence of asthma and the COVID-19 infection associated with behavioral changes in Lebanese adolescents?
Fuente: Allergol. immunopatol;52(2):68-79, mar. 2024. tab.
Idioma: en.
doi: 10.15586/aei.v52i2.1054.
Resumen: Background: Little evidence is available about psychological stressors in Lebanese asthmatic adolescents, where health-risk behaviors are a serious threat to public health. In addition, the COVID-19 epidemic has had a substantial influence on adolescents' mental health globally, especially in Lebanon, where the ongoing economic and political challenges have largely impacted their psychological well-being. This study aimed to explore the association of asthma and the COVID-19 infection with behaviors among Lebanese adolescents. Methods: Data were collected in July 2023, using the snowball sampling technique. Inclusion criteria for participation in the study included being of a resident and citizen of Lebanon and aged 12û18 years. Behavioral problems were assessed using the Youth Self-Report (YSR) scale, which yields nine subscales (anxious/depressed, withdrawn/depressed, somatic complaints, social problems, thought problems, attention problems, rule-breaking behavior, aggressive behavior, and other problems) and a total score. Results: Asthma was significantly associated with somatic complaints (Beta [β] = 2.98), attention problems (β = 0.01), and other behavioral problems (β = 0.68). Having contracted the COVID-19 infection, compared to healthy asymptomatic state (β = 1.55), was significantly associated with more anxious behaviors. In the case of stratifying the analysis in terms of gender, the results showed that the presence of asthma was significantly associated with more social behaviors (β = 3.31), thought problems (β = 2.91), attention problems (β = 0.02), other behavioral problems (β = 1.71), and total behavioral problems (β = 5.71) in males...(AU)
Descriptores: asma
estrés psicológico
/epidemiología
COVID-19/epidemiología
salud mental
trastornos mentales
cribado sistemático
morbilidad/tendencias
-Líbano
Límites: seres humanos
niño
adolescente
Tipo de Publicación: informes de casos
Responsable: ES15.1 - BNCS


  7 / 2067 IBECS  
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Id: 231087
Autor: Horiuchi, Yasuhiro.
Título: Allergic rhinitis: therapeutic strategies update Lactococcus lactis Plasma and tranilastûroxithromycin combination
Fuente: Allergol. immunopatol;52(2):1-2, mar. 2024. ilus.
Idioma: en.
doi: 10.15586/aei.v52i2.1010.
Descriptores: rinitis alérgica
terapéutica
Lactococcus lactis
plasma
roxitromicina
probióticos
inmunoterapia
pacientes
-Japón
Límites: seres humanos
Tipo de Publicación: carta
Responsable: ES15.1 - BNCS


  8 / 2067 IBECS  
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Id: 231086
Autor: Lu, Xin; Dai, Shouqian; Li, Pengfei; Zhou, Yuqian; Xu, Feng.
Título: YBX-1 alleviates sepsis-stimulated lung epithelial cell injury
Fuente: Allergol. immunopatol;52(2):60-67, mar. 2024. ilus, graf.
Idioma: en.
doi: 10.15586/aei.v52i2.1068.
Resumen: Objective: To explore the role of Y-box binding protein 1 (YBX-1) in the lipopolysaccharide (LPS)-stimulated inflammation and oxidative stress of BEAS-2B cell line and clarify the underlying mechanism. Methods: LPS-stimulated BEAS-2B cells were used as a cell model of sepsis-stimulated acute lung injury (ALI). Immunoblot and quantitative polymerase chain reaction assays were used to detect the expression of YBX-1 in LPS-stimulated BEAS-2B cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide, TdT-mediated dUTP nick end labeling, and immunoblot assays were conducted to determine the effects of YBX-1 on cell survival. JC-1 staining and adenosine triphosphate production were used to detect the effects of YBX-1 on mitochondrial function. Immunostaining and enzyme-linked immunosorbent serologic assay were performed to examine the effects of YBX-1 on the inflammation and oxidative stress of cells. Immunoblot assay was conducted to confirm the mechanism. Results: YBX-1 was lowly expressed in LPS-stimulated BEAS-2B cells and enhanced the survival of LPS-stimulated lung epithelial cells. In addition, YBX-1 improved mitochondrial function of LPS-stimulated BEAS-2B cells. YBX-1 inhibited the inflammation and oxidative stress of LPS-stimulated BEAS-2B cells. Mechanically, YBX-1 inhibited mitogen-activated protein kinase (MAPK) axis, thereby alleviating sepsis-stimulated ALI. Conclusion: YBX-1 alleviated inflammation and oxidative stress of LPS-stimulated BEAS-2B cells via MAPK axis. (AU)
Descriptores: proteína 1 de unión a Y-box
inflamación
lipopolisacáridos
lesión pulmonar aguda
sepsis
supervivencia celular
células epiteliales alveolares
Límites: seres humanos
Tipo de Publicación: ESTUDIO DE EVALUACION
Responsable: ES15.1 - BNCS


  9 / 2067 IBECS  
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Id: 231085
Autor: Azzi, Vanessa; Malaeb, Diana; El Khatib, Sami; Sakr, Fouad; Dabbous, Mariam; Hallit, Souheil; Soufia, Michel.
Título: Association of behaviors and asthma control in a sample of Lebanese adolescents with asthma
Fuente: Allergol. immunopatol;52(2):51-59, mar. 2024. tab.
Idioma: en.
doi: 10.15586/aei.v52i2.1057.
Resumen: Background: The relationship between behavioral problems and asthma is bidirectional; while the presence of a chronic disease such as asthma might predispose the person to stress, anxiety, and other behavioral issues, behavioral problems might in turn cause uncontrolled asthma through nonadherence to asthma management strategies. In Lebanon, behavioral problems and uncontrolled asthma could be of significant concern for adolescents. Consequently, we found it necessary to evaluate association between behavioral problems and uncontrolled asthma in a sample of Lebanese adolescents. Methods: Data for this cross-sectional study were collected using the snowball sampling technique in July 2023. The questionnaire was developed with Google Forms and distributed to participants via social media platforms and messaging applications. The Asthma Control Test (ACT) was used to check for uncontrolled asthma, and the Youth Self-Report (YSR) scale was used to assess behavioral problems. It yields nine subscales (anxiousûdepressed, withdrawnûdepressed, somatic complaints, social problems, thought problems, attention problems, rule-breaking behavior, aggressive behavior, and other problems) and a total score. Results: When taking each behavior score as an independent variable, older age was associated with lower ACT scores (more controlled asthma); F(15, 186) = 3.66, P = 0.014, and 95% Confidence Interval (CI) [-0.85, -0.10]. Living in a rural area, compared to urban was associated with higher ACT scores, P = 0.018, and 95% Confidence Interval (CI) [0.28, 2.94]. The intake of the COVID-19 vaccine, P = 0.003 and 95% CI [0.73, 3.55]; waterpipe smoking, P = 0.017 and 95% CI [0.38, 3.85]; and having more somatic complaints, P = 0.005 and 95% CI [0.04, 0.25], also were significantly associated with higher ACT scores (more uncontrolled asthma)...(AU)
Descriptores: asma
enfermedad crónica
ansiedad
VACUNAS CONTRA LA COVID-19
fumar en pipa de agua
-Líbano
estudios transversales
Límites: seres humanos
adolescente
Tipo de Publicación: estudio comparativo
Responsable: ES15.1 - BNCS


  10 / 2067 IBECS  
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Id: 231084
Autor: Rao, Yunwei; Lin, Hai; Rao, Huan; Rao, Yunkun; Tang, Xiaoyuan; Zuo, Huimin; Wang, Ying.
Título: Isoegomaketone alleviates inflammatory response and oxidative stress in sepsis lung injury
Fuente: Allergol. immunopatol;52(2):16-22, mar. 2024. graf, ilus.
Idioma: en.
doi: 10.15586/aei.v52i2.1030.
Resumen: Background: Sepsis is a life-threatening condition characterized by acute organ dysfunction, which frequently leads to acute lung injury (ALI) in approximately 40% of cases. Isoegomaketone (IK) is a constituent of essential oil found in P. frutescens, known for its diverse biological properties, including anti-inflammatory and antitumor effects. However, the regulatory impact of IK on ALI in the context of sepsis remains poorly understood. Methods: Pathological alterations in lung tissues were assessed using hematoxylin and eosin staining. Enumeration of total leukocytes and neutrophils in bronchoalveolar lavage fluid (BALF) was performed using a hematocytometer, while the levels of interleukin (IL)-6, IL-1β, IL-10, and IL-17 in BALF were quantified using enzyme-linked immunosorbent serological assay. In addition, the levels of malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and glutathione (GSH) in lung tissues were assessed using respective commercial kits; cell apoptosis was evaluated using the terminal deoxynucleotide transferase--mediated dUTP nick end-labeling assay, and protein expressions were determined through Western blot analysis. Results: Our findings revealed that cecal ligation and puncture (CLP) treatment in mice induced severe lung injury, characterized by increased lung injury scores, significant bleeding, neutrophil infiltration, and alveolar edema. However, treatment with IK at a dose of 10 mg/kg ameliorated CLP-induced lung injury, while IK dose of 5 mg/kg showed no significant effect. Additionally, IK treatment at 10 mg/kg reduced CLP-induced inflammation by decreasing levels of IL-6, IL-1β, IL-10, and IL-17. Furthermore, IK at 10 mg/kg attenuated CLP-induced oxidative stress by modulating levels of MDA, MPO, SOD, and GSH... (AU)
Descriptores: sepsis
lesión pulmonar aguda
aceites volátiles
Perilla frutescens
antiinflamatorios
pruebas de cribado de medicamentos antitumorales
tinción y etiquetado
hematoxilina
Límites: ratas
Tipo de Publicación: estudio observacional veterinario
Responsable: ES15.1 - BNCS



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